Antidepressant but not prophylactic ketamine administration alters calretinin and calbindin expression in the ventral hippocampus
Ketamine has been found to have rapid, long-lasting antidepressant effects in treatment-
resistant (TR) patients with major depressive disorder (MDD). Recently, we have also shown …
resistant (TR) patients with major depressive disorder (MDD). Recently, we have also shown …
[HTML][HTML] Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2
A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive‐like rats
H Michaëlsson, M Andersson, J Svensson… - Acta …, 2019 - Wiley Online Library
Aim Major depressive disorder is a common and debilitating condition with substantial
economic impact. Treatment options, although effective, are aimed at relieving the symptoms …
economic impact. Treatment options, although effective, are aimed at relieving the symptoms …
Molecular Mechanism and Clinical Relevance of Ketamine as Rapid‐Acting Antidepressant
V Pešić, J Petrović, MM Jukić - Drug development research, 2016 - Wiley Online Library
ABSTRACT Preclinical Research The emergence of rapid‐acting antidepressants such as
ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine …
ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine …
Myelin-associated oligodendrocytic basic protein-dependent myelin repair confers the long-lasting antidepressant effect of ketamine
C Huang, Z Wu, D Wang, Y Qu, J Zhang, R Jiang… - Molecular …, 2023 - nature.com
Ketamine exhibits rapid and sustained antidepressant effects. As decreased myelination has
been linked to depression pathology, changes in myelination may be a pivotal mechanism …
been linked to depression pathology, changes in myelination may be a pivotal mechanism …
Chronic administration of ketamine induces cognitive deterioration by restraining synaptic signaling
Y Luo, Y Yu, M Zhang, H He, N Fan - Molecular Psychiatry, 2021 - nature.com
The discovery of the rapid antidepressant effects of ketamine has arguably been the most
important advance in depression treatment. Recently, it was reported that repeated long …
important advance in depression treatment. Recently, it was reported that repeated long …
Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine
Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …
Uncovering the underlying mechanisms of ketamine as a novel antidepressant
S Xu, X Yao, B Li, R Cui, C Zhu, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Major depressive disorder (MDD) is a devastating psychiatric disorder which exacts
enormous personal and social-economic burdens. Ketamine, an N-methyl-D-aspartate …
enormous personal and social-economic burdens. Ketamine, an N-methyl-D-aspartate …
Ketamine and its metabolite,(2R, 6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression
Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the
pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and …
pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and …
Ketamine's antidepressant effect: focus on ketamine mechanisms of action
P De Maricourt, T Jay, P Goncalves, H Lôo… - L' …, 2014 - pubmed.ncbi.nlm.nih.gov
Background In recent years, discovery of ketamine's fast and powerful antidepressant effects
for treatment-resistant depression (TRD) has led to rethinking of the pathophysiology of …
for treatment-resistant depression (TRD) has led to rethinking of the pathophysiology of …