Ketamine has been found to have rapid, long-lasting antidepressant effects in treatment-
resistant (TR) patients with major depressive disorder (MDD). Recently, we have also shown …

A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …

Aim Major depressive disorder is a common and debilitating condition with substantial
economic impact. Treatment options, although effective, are aimed at relieving the symptoms …

ABSTRACT Preclinical Research The emergence of rapid‐acting antidepressants such as
ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine …

Ketamine exhibits rapid and sustained antidepressant effects. As decreased myelination has
been linked to depression pathology, changes in myelination may be a pivotal mechanism …

The discovery of the rapid antidepressant effects of ketamine has arguably been the most
important advance in depression treatment. Recently, it was reported that repeated long …

Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …

Major depressive disorder (MDD) is a devastating psychiatric disorder which exacts
enormous personal and social-economic burdens. Ketamine, an N-methyl-D-aspartate …

Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the
pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and …

Background In recent years, discovery of ketamine's fast and powerful antidepressant effects
for treatment-resistant depression (TRD) has led to rethinking of the pathophysiology of …