Recent advances in synthetic biology for engineering isoprenoid production in yeast

CE Vickers, TC Williams, B Peng, J Cherry - Current opinion in chemical …, 2017 - Elsevier
Highlights•Isoprenoids are industrially important natural products.•Yeast are key industrial
production vehicles.•New synthetic biology approaches in recent years are reviewed.•Future …

[HTML][HTML] Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast

X Cao, S Yang, C Cao, YJ Zhou - Synthetic and systems biotechnology, 2020 - Elsevier
Current yeast metabolic engineering in isoprenoids production mainly focuses on rewiring of
cytosolic metabolic pathway. However, the precursors, cofactors and the enzymes are …

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae

S Tippmann, Y Chen, V Siewers… - Biotechnology …, 2013 - Wiley Online Library
Isoprenoids denote the largest group of chemicals in the plant kingdom and are employed
for a wide range of applications in the food and pharmaceutical industry. In recent years …

[HTML][HTML] Microbial Platform for Terpenoid Production: Escherichia coli and Yeast

C Wang, M Liwei, JB Park, SH Jeong, G Wei… - Frontiers in …, 2018 - frontiersin.org
Terpenoids, also called isoprenoids, are a large and highly diverse family of natural
products with important medical and industrial properties. However, a limited production of …

Production of isoprenoid pharmaceuticals by engineered microbes

MCY Chang, JD Keasling - Nature chemical biology, 2006 - nature.com
Throughout human history, natural products have been the foundation for the discovery and
development of therapeutics used to treat diseases ranging from cardiovascular disease to …

Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae

GR Navale, MS Dharne, SS Shinde - Applied Microbiology and …, 2021 - Springer
Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …

Metabolic engineering of microorganisms for isoprenoid production

J Kirby, JD Keasling - Natural product reports, 2008 - pubs.rsc.org
Covering: up to the end of 2007 Isoprenoids are ubiquitous in nature and range from
essential cell components to unique secondary metabolites. The two isoprenoid biosynthetic …

Production of natural products through metabolic engineering of Saccharomyces cerevisiae

A Krivoruchko, J Nielsen - Current opinion in biotechnology, 2015 - Elsevier
Highlights•Metabolic engineering enables the microbial production of many compounds.•
Advances in engineering of yeast for production of valuable isoprenoids and aromatics are …

[HTML][HTML] Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae

X Lv, F Wang, P Zhou, L Ye, W Xie, H Xu… - Nature …, 2016 - nature.com
Microbial production of isoprene from renewable feedstock is a promising alternative to
traditional petroleum-based processes. Currently, efforts to improve isoprenoid production in …

Pathway engineering for functional isoprenoids

N Misawa - Current opinion in biotechnology, 2011 - Elsevier
Pathway engineering is to engineer biosynthetic pathways for compounds of interests in
heterologous organisms such as microbes and higher plants, which has also been one of …