[HTML][HTML] Fermentation strategies for production of pharmaceutical terpenoids in engineered yeast

E Carsanba, M Pintado, C Oliveira - Pharmaceuticals, 2021 - mdpi.com
Terpenoids, also known as isoprenoids, are a broad and diverse class of plant natural
products with significant industrial and pharmaceutical importance. Many of these natural …

Advances in metabolic engineering paving the way for the efficient biosynthesis of terpenes in yeasts

W Li, L Cui, J Mai, TQ Shi, L Lin, ZG Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Terpenes are a large class of secondary metabolites with diverse structures and functions
that are commonly used as valuable raw materials in food, cosmetics, and medicine. With …

Metabolic engineering and synthetic biology approaches driving isoprenoid production in Escherichia coli

C Wang, B Zada, G Wei, SW Kim - Bioresource Technology, 2017 - Elsevier
Isoprenoids comprise the largest family of natural organic compounds with many useful
applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments …

Strategies for terpenoid overproduction and new terpenoid discovery

G Bian, Z Deng, T Liu - Current Opinion in Biotechnology, 2017 - Elsevier
Highlights•In vitro reconstitution of mevalonate pathway provides key information for
terpenoid overproduction.•Microbial host and pathway engineering for terpenoid …

Developing fermentative terpenoid production for commercial usage

MD Leavell, DJ McPhee, CJ Paddon - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Commercial production of isoprenoids from naturally producing organisms is
rare.•Heterologous isoprenoid production from yeast is a commercial reality.•The …

Cell free biosynthesis of isoprenoids from isopentenol

VCA Ward, AO Chatzivasileiou… - Biotechnology and …, 2019 - Wiley Online Library
Cell‐free systems are growing in importance for the biosynthesis of complex molecules.
These systems combine the precision of traditional chemistry with the versatility of biology in …

Enhanced isoprenoid production from xylose by engineered Saccharomyces cerevisiae

S Kwak, SR Kim, H Xu, GC Zhang… - Biotechnology and …, 2017 - Wiley Online Library
Saccharomyces cerevisiae has limited capabilities for producing fuels and chemicals
derived from acetyl‐CoA, such as isoprenoids, due to a rigid flux partition toward ethanol …

Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts

R Muntendam, E Melillo, A Ryden, O Kayser - Applied microbiology and …, 2009 - Springer
Terpenoids belong to the largest class of natural compounds and are produced in all living
organisms. The isoprenoid skeleton is based on assembling of C5 building blocks, but the …

Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels

Y Zhang, J Nielsen, Z Liu - FEMS Yeast Research, 2017 - academic.oup.com
Terpenoids represent a large class of natural products with significant commercial
applications. These chemicals are currently mainly obtained through extraction from plants …

Biosynthesis and engineering of isoprenoid small molecules

ST Withers, JD Keasling - Applied microbiology and biotechnology, 2007 - Springer
Isoprenoid secondary metabolites are a rich source of commercial products that have not
been fully explored. At present, there are isoprenoid products used in cancer therapy, the …