[HTML][HTML] Fermentation strategies for production of pharmaceutical terpenoids in engineered yeast
E Carsanba, M Pintado, C Oliveira - Pharmaceuticals, 2021 - mdpi.com
Terpenoids, also known as isoprenoids, are a broad and diverse class of plant natural
products with significant industrial and pharmaceutical importance. Many of these natural …
products with significant industrial and pharmaceutical importance. Many of these natural …
Advances in metabolic engineering paving the way for the efficient biosynthesis of terpenes in yeasts
W Li, L Cui, J Mai, TQ Shi, L Lin, ZG Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Terpenes are a large class of secondary metabolites with diverse structures and functions
that are commonly used as valuable raw materials in food, cosmetics, and medicine. With …
that are commonly used as valuable raw materials in food, cosmetics, and medicine. With …
Metabolic engineering and synthetic biology approaches driving isoprenoid production in Escherichia coli
Isoprenoids comprise the largest family of natural organic compounds with many useful
applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments …
applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments …
Strategies for terpenoid overproduction and new terpenoid discovery
Highlights•In vitro reconstitution of mevalonate pathway provides key information for
terpenoid overproduction.•Microbial host and pathway engineering for terpenoid …
terpenoid overproduction.•Microbial host and pathway engineering for terpenoid …
Developing fermentative terpenoid production for commercial usage
MD Leavell, DJ McPhee, CJ Paddon - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Commercial production of isoprenoids from naturally producing organisms is
rare.•Heterologous isoprenoid production from yeast is a commercial reality.•The …
rare.•Heterologous isoprenoid production from yeast is a commercial reality.•The …
Cell free biosynthesis of isoprenoids from isopentenol
VCA Ward, AO Chatzivasileiou… - Biotechnology and …, 2019 - Wiley Online Library
Cell‐free systems are growing in importance for the biosynthesis of complex molecules.
These systems combine the precision of traditional chemistry with the versatility of biology in …
These systems combine the precision of traditional chemistry with the versatility of biology in …
Enhanced isoprenoid production from xylose by engineered Saccharomyces cerevisiae
Saccharomyces cerevisiae has limited capabilities for producing fuels and chemicals
derived from acetyl‐CoA, such as isoprenoids, due to a rigid flux partition toward ethanol …
derived from acetyl‐CoA, such as isoprenoids, due to a rigid flux partition toward ethanol …
Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts
R Muntendam, E Melillo, A Ryden, O Kayser - Applied microbiology and …, 2009 - Springer
Terpenoids belong to the largest class of natural compounds and are produced in all living
organisms. The isoprenoid skeleton is based on assembling of C5 building blocks, but the …
organisms. The isoprenoid skeleton is based on assembling of C5 building blocks, but the …
Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels
Terpenoids represent a large class of natural products with significant commercial
applications. These chemicals are currently mainly obtained through extraction from plants …
applications. These chemicals are currently mainly obtained through extraction from plants …
Biosynthesis and engineering of isoprenoid small molecules
ST Withers, JD Keasling - Applied microbiology and biotechnology, 2007 - Springer
Isoprenoid secondary metabolites are a rich source of commercial products that have not
been fully explored. At present, there are isoprenoid products used in cancer therapy, the …
been fully explored. At present, there are isoprenoid products used in cancer therapy, the …