Rewriting yeast central carbon metabolism for industrial isoprenoid production
AL Meadows, KM Hawkins, Y Tsegaye, E Antipov… - Nature, 2016 - nature.com
A bio-based economy has the potential to provide sustainable substitutes for petroleum-
based products and new chemical building blocks for advanced materials. We previously …
based products and new chemical building blocks for advanced materials. We previously …
Metabolic engineering strategies for sustainable terpenoid flavor and fragrance synthesis
Terpenoids derived from plant material are widely applied in the flavor and fragrance
industry. Traditional extraction methods are unsustainable, but microbial synthesis offers a …
industry. Traditional extraction methods are unsustainable, but microbial synthesis offers a …
New frontiers: harnessing pivotal advances in microbial engineering for the biosynthesis of plant-derived terpenoids
MS Belcher, J Mahinthakumar, JD Keasling - Current opinion in …, 2020 - Elsevier
Highlights•Terpenoids are a vast and diverse class of compounds with applications in both
the industrial and human health spaces.•Computational biology and gene discovery enable …
the industrial and human health spaces.•Computational biology and gene discovery enable …
Metabolic engineering of microbes for monoterpenoid production
K Zhu, J Kong, B Zhao, L Rong, S Liu, Z Lu… - Biotechnology …, 2021 - Elsevier
Monoterpenoids are an important class of natural products that are derived from the
condensation of two five‑carbon isoprene subunits. They are widely used for flavouring …
condensation of two five‑carbon isoprene subunits. They are widely used for flavouring …
Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast
Miltiradiene is a key intermediate in the biosynthesis of many important natural diterpene
compounds with significant pharmacological activity, including triptolide, tanshinones …
compounds with significant pharmacological activity, including triptolide, tanshinones …
Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli
H Harada, N Misawa - Applied microbiology and biotechnology, 2009 - Springer
Isoprenoids, also referred to as terpenes, are the most diverse class of natural products
appearing in a variety of natural sources, specifically in higher plants, and have a wide …
appearing in a variety of natural sources, specifically in higher plants, and have a wide …
Widespread biosynthesis of 16-carbon terpenoids in bacteria
YT Duan, A Koutsaviti, M Harizani, C Ignea… - Nature Chemical …, 2023 - nature.com
Terpenoids are the most diverse group of specialized metabolites with numerous
applications. Their biosynthesis is based on the five-carbon isoprene building block and, as …
applications. Their biosynthesis is based on the five-carbon isoprene building block and, as …
Metabolic Engineering of Yarrowia lipolytica for Terpenoid Production: Tools and Strategies
TL Zhang, HW Yu, LD Ye - ACS Synthetic Biology, 2023 - ACS Publications
Terpenoids are a diverse group of compounds with isoprene units as basic building blocks.
They are widely used in the food, feed, pharmaceutical, and cosmetic industries due to their …
They are widely used in the food, feed, pharmaceutical, and cosmetic industries due to their …
Metabolic engineering for plant natural product biosynthesis in microbes
JA Chemler, MAG Koffas - Current opinion in biotechnology, 2008 - Elsevier
Plant natural products (NPs) not only serve many functions in an organism's survivability but
also demonstrate important pharmacological activities. Isolation of NPs from native sources …
also demonstrate important pharmacological activities. Isolation of NPs from native sources …
Metabolic engineering of isoprenoids
R Barkovich, JC Liao - Metabolic engineering, 2001 - Elsevier
The metabolic engineering of natural products has begun to prosper in the past few years
due to genomic research and the discovery of biosynthetic genes. While the biosynthetic …
due to genomic research and the discovery of biosynthetic genes. While the biosynthetic …