Rewriting yeast central carbon metabolism for industrial isoprenoid production

AL Meadows, KM Hawkins, Y Tsegaye, E Antipov… - Nature, 2016 - nature.com
A bio-based economy has the potential to provide sustainable substitutes for petroleum-
based products and new chemical building blocks for advanced materials. We previously …

Metabolic engineering strategies for sustainable terpenoid flavor and fragrance synthesis

X Chen, C Zhang, ND Lindley - Journal of agricultural and food …, 2019 - ACS Publications
Terpenoids derived from plant material are widely applied in the flavor and fragrance
industry. Traditional extraction methods are unsustainable, but microbial synthesis offers a …

New frontiers: harnessing pivotal advances in microbial engineering for the biosynthesis of plant-derived terpenoids

MS Belcher, J Mahinthakumar, JD Keasling - Current opinion in …, 2020 - Elsevier
Highlights•Terpenoids are a vast and diverse class of compounds with applications in both
the industrial and human health spaces.•Computational biology and gene discovery enable …

Metabolic engineering of microbes for monoterpenoid production

K Zhu, J Kong, B Zhao, L Rong, S Liu, Z Lu… - Biotechnology …, 2021 - Elsevier
Monoterpenoids are an important class of natural products that are derived from the
condensation of two five‑carbon isoprene subunits. They are widely used for flavouring …

Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast

T Hu, J Zhou, Y Tong, P Su, X Li, Y Liu, N Liu, X Wu… - Metabolic …, 2020 - Elsevier
Miltiradiene is a key intermediate in the biosynthesis of many important natural diterpene
compounds with significant pharmacological activity, including triptolide, tanshinones …

Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli

H Harada, N Misawa - Applied microbiology and biotechnology, 2009 - Springer
Isoprenoids, also referred to as terpenes, are the most diverse class of natural products
appearing in a variety of natural sources, specifically in higher plants, and have a wide …

Widespread biosynthesis of 16-carbon terpenoids in bacteria

YT Duan, A Koutsaviti, M Harizani, C Ignea… - Nature Chemical …, 2023 - nature.com
Terpenoids are the most diverse group of specialized metabolites with numerous
applications. Their biosynthesis is based on the five-carbon isoprene building block and, as …

Metabolic Engineering of Yarrowia lipolytica for Terpenoid Production: Tools and Strategies

TL Zhang, HW Yu, LD Ye - ACS Synthetic Biology, 2023 - ACS Publications
Terpenoids are a diverse group of compounds with isoprene units as basic building blocks.
They are widely used in the food, feed, pharmaceutical, and cosmetic industries due to their …

Metabolic engineering for plant natural product biosynthesis in microbes

JA Chemler, MAG Koffas - Current opinion in biotechnology, 2008 - Elsevier
Plant natural products (NPs) not only serve many functions in an organism's survivability but
also demonstrate important pharmacological activities. Isolation of NPs from native sources …

Metabolic engineering of isoprenoids

R Barkovich, JC Liao - Metabolic engineering, 2001 - Elsevier
The metabolic engineering of natural products has begun to prosper in the past few years
due to genomic research and the discovery of biosynthetic genes. While the biosynthetic …