Strategies for enhancing the permeation of CNS-active drugs through the blood-brain barrier: a review
I Zeiadeh, A Najjar, R Karaman - Molecules, 2018 - mdpi.com
Background: The blood brain barrier (BBB) is a dynamic and functional structure which
poses a vast challenge in the development of drugs acting on the central nervous system …
poses a vast challenge in the development of drugs acting on the central nervous system …
Nanoparticles as a carrier system for drug delivery across blood brain barrier
A Sarkar, I Fatima… - Current drug …, 2017 - ingentaconnect.com
Brain, the centre of the nervous system and an integral part the body, is protected by two
anatomical and physiological barriers-Blood-Brain Barrier (BBB) and Blood-Cerebrospinal …
anatomical and physiological barriers-Blood-Brain Barrier (BBB) and Blood-Cerebrospinal …
Brain drug delivery technologies: novel approaches for transporting therapeutics
J Temsamani, JM Scherrmann, AR Rees… - … science & technology …, 2000 - Elsevier
The blood–brain barrier (BBB) denies many therapeutic agents access to brain tumours and
other diseases of the central nervous system (CNS). Despite remarkable advances in our …
other diseases of the central nervous system (CNS). Despite remarkable advances in our …
Overcoming the blood–brain barrier in neurodegenerative disorders and brain tumours
Z Ebrahimi, S Talaei, S Aghamiri… - IET …, 2020 - Wiley Online Library
Drug delivery is one of the major challenges in the treatment of central nervous system
disorders. The brain needs to be protected from harmful agents, which are done by the …
disorders. The brain needs to be protected from harmful agents, which are done by the …
Drug delivery to the brain
Drugs for the central nervous system (CNS) have gained huge market potential in recent
years. Owing to the changes in lifestyles and a dramatic increase in the life expectancy the …
years. Owing to the changes in lifestyles and a dramatic increase in the life expectancy the …
Carrier-mediated transportation through BBB
NU Khan, T Miao, X Ju, Q Guo, L Han - Brain targeted drug delivery system, 2019 - Elsevier
Drug delivery has achieved great development in the last two decades, but it remains a
difficult task to regulate drug entry into the brain. However, recent progress in studies of the …
difficult task to regulate drug entry into the brain. However, recent progress in studies of the …
Nano carriers for drug transport across the blood–brain barrier
X Li, J Tsibouklis, T Weng, B Zhang, G Yin… - Journal of drug …, 2017 - Taylor & Francis
Effective therapy lies in achieving a therapeutic amount of drug to the proper site in the body
and then maintaining the desired drug concentration for a sufficient time interval to be …
and then maintaining the desired drug concentration for a sufficient time interval to be …
Crossing the blood–brain barrier: recent advances in drug delivery to the brain
CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …
Drug delivery across the blood-brain barrier
A Lalatsa, AG Schätzlein… - Comprehensive …, 2011 - pureportal.strath.ac.uk
Brain diseases are a leading cause of disability, morbidity, and mortality. However, the
treatment of brain diseases (eg, neurodegenerative diseases, psychiatric disorders, pain …
treatment of brain diseases (eg, neurodegenerative diseases, psychiatric disorders, pain …
Concepts, technologies, and practices for drug delivery past the blood–brain barrier to the central nervous system
L Crawford, J Rosch, D Putnam - Journal of Controlled Release, 2016 - Elsevier
While neurodegenerative diseases and cancers are on the rise, treatments for diseases of
the central nervous system (CNS) remain limited. The blood brain barrier (BBB) poses the …
the central nervous system (CNS) remain limited. The blood brain barrier (BBB) poses the …