Background: The blood brain barrier (BBB) is a dynamic and functional structure which
poses a vast challenge in the development of drugs acting on the central nervous system …

Brain, the centre of the nervous system and an integral part the body, is protected by two
anatomical and physiological barriers-Blood-Brain Barrier (BBB) and Blood-Cerebrospinal …

The blood–brain barrier (BBB) denies many therapeutic agents access to brain tumours and
other diseases of the central nervous system (CNS). Despite remarkable advances in our …

Drug delivery is one of the major challenges in the treatment of central nervous system
disorders. The brain needs to be protected from harmful agents, which are done by the …

Drugs for the central nervous system (CNS) have gained huge market potential in recent
years. Owing to the changes in lifestyles and a dramatic increase in the life expectancy the …

Drug delivery has achieved great development in the last two decades, but it remains a
difficult task to regulate drug entry into the brain. However, recent progress in studies of the …

Effective therapy lies in achieving a therapeutic amount of drug to the proper site in the body
and then maintaining the desired drug concentration for a sufficient time interval to be …

CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

Brain diseases are a leading cause of disability, morbidity, and mortality. However, the
treatment of brain diseases (eg, neurodegenerative diseases, psychiatric disorders, pain …

While neurodegenerative diseases and cancers are on the rise, treatments for diseases of
the central nervous system (CNS) remain limited. The blood brain barrier (BBB) poses the …