Heme oxygenase-1 (HO-1) catalyzes the degradation of heme and forms antioxidant bile
pigments as well as the signaling molecule carbon monoxide. HO-1 is inducible in response …

Heme oxygenase (HO)-1 is the inducible isoform of the rate-limiting enzyme of heme
degradation. HO regulates the cellular content of the pro-oxidant heme and produces …

Significance: Many reports have underscored the importance of the heme degradation
pathway that is regulated by heme oxygenase (HO). This reaction releases bile pigments …

Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is an integral
membrane protein of the smooth endoplasmic reticulum. However, we detected an HO-1 …

Heme oxygenase-1 (HO-1) is an essential enzyme in heme catabolism and is characterized
by its inducibility in response to various environmental factors, including its substrate heme …

Disturbances of intracellular redox equilibrium may alter eukaryotic gene expression
patterns in the manifestation of an adaptive stress response. The inducible heme oxygenase …

The HO-1 isoenzyme is an early stress response gene regulated by many forms of oxidative
stress. The HO-2 isoenzyme is predominantly a constitutive enzyme, which may serve to …

Heme oxygenase (HO) catalyzes the oxidative cleavage of the α-mesocarbon of Fe-
protoporphyrin-IX yielding equimolar amounts of biliverdin-IXα, free divalent iron, and …

Oxidative stresses such as oxidant stimuli, inflammation, exposure to xenobiotics, or ionizing
irradiation provoke cellular protective responses, principally involving transcriptional …

Heme oxygenase (HO) catalyzes the rate-limiting step in heme degradation, producing iron,
carbon monoxide, and bilirubin/biliverdin. HO consists of two isozymes: HO-1, which is an …