Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity
S Yamaguchi, A Tanimoto, K Otsuguro, H Hibino… - Journal of Biological …, 2014 - ASBMB
Transient receptor potential (TRP) channel melastatin subfamily member 4 (TRPM4) is a
broadly expressed nonselective monovalent cation channel. TRPM4 is activated by …
broadly expressed nonselective monovalent cation channel. TRPM4 is activated by …
TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca2+ Sensitivity but Not Significance of PI(4,5)P2
S Yamaguchi, A Tanimoto, S Iwasa… - International journal of …, 2019 - mdpi.com
Transient receptor potential melastatin member 4 (TRPM4) and 5 (TRPM5) channels are
Ca2+-activated nonselective cation channels. Intracellular Ca2+ is the most important …
Ca2+-activated nonselective cation channels. Intracellular Ca2+ is the most important …
The Ca2+‐activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5‐biphosphate
B Nilius, F Mahieu, J Prenen, A Janssens… - The EMBO …, 2006 - embopress.org
Transient receptor potential (TRP) channel, melastatin subfamily (TRPM) 4 is a Ca2+‐
activated monovalent cation channel that depolarizes the plasma membrane and thereby …
activated monovalent cation channel that depolarizes the plasma membrane and thereby …
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4
TRPM4, a Ca 2+-activated cation channel of the transient receptor potential superfamily,
undergoes a fast desensitization to Ca 2+. The mechanisms underlying the alterations in Ca …
undergoes a fast desensitization to Ca 2+. The mechanisms underlying the alterations in Ca …
Alternative splicing switches the divalent cation selectivity of TRPM3 channels
J Oberwinkler, A Lis, KM Giehl, V Flockerzi… - Journal of Biological …, 2005 - ASBMB
TRPM3 is a poorly understood member of the large family of transient receptor potential
(TRP) ion channels. Here we describe five novel splice variants of TRPM3, TRPM3α1–5 …
(TRP) ion channels. Here we describe five novel splice variants of TRPM3, TRPM3α1–5 …
Lys1110 of TRPM2 is critical for channel activation
TK Kim, JH Nam, WG Ahn, NH Kim, HY Ham… - Biochemical …, 2013 - portlandpress.com
TRPM2 (transient receptor potential melastatin 2) is a non-selective Ca2+-permeable cation
channel activated by ADPR (adenosine diphosphoribose) and H2O2. It is widely expressed …
channel activated by ADPR (adenosine diphosphoribose) and H2O2. It is widely expressed …
Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels
J Frühwald, JC Londono, S Dembla… - Journal of Biological …, 2012 - ASBMB
TRPM3 channels form ionotropic steroid receptors in the plasma membrane of pancreatic β
and dorsal root ganglion cells and link steroid hormone signaling to insulin release and pain …
and dorsal root ganglion cells and link steroid hormone signaling to insulin release and pain …
Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function
ZZ Mei, HJ Mao, LH Jiang - American Journal of Physiology …, 2006 - journals.physiology.org
TRPM2 proteins belong to the melastatin-related transient receptor potential or TRPM
subfamily and form Ca2+-permeable cationic channels activated by intracellular adenosine …
subfamily and form Ca2+-permeable cationic channels activated by intracellular adenosine …
Identification of the phosphorylation sites on intact TRPM7 channels from mammalian cells
TY Kim, SK Shin, MY Song, JE Lee, KS Park - Biochemical and biophysical …, 2012 - Elsevier
Transient receptor potential melastatin 7 (TRPM7) channels are divalent cation-selective ion
channels that are permeable to Ca2+ and Mg2+. TRPM7 is ubiquitously expressed in …
channels that are permeable to Ca2+ and Mg2+. TRPM7 is ubiquitously expressed in …
Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity
Y Luo, X Yu, C Ma, J Luo, W Yang - Frontiers in Pharmacology, 2018 - frontiersin.org
As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is
involved in many physiological and pathological processes including warmth sensing …
involved in many physiological and pathological processes including warmth sensing …