Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

In the developing nervous system, nerve cells and axons respond to various attractive and
repulsive guidance cues while traveling to their final destination. Netrins are bifunctional …

Extracellular cues direct axon extension by regulating growth cone morphology. The netrin-1
receptor deleted in colorectal cancer (DCC) is required for commissural axon extension to …

Netrin-1 is a guidance cue that can trigger either attraction or repulsion effects on migrating
axons of neurons, depending on the repertoire of receptors available on the growth cone …

The name netrin is derived from the Sanskrit Netr, meaning'guide'. Netrins are a family of
extracellular proteins that direct cell and axon migration during embryogenesis. Three …

Neuronal growth cones are guided to their targets by attractive and repulsive guidance cues.
In mammals, netrin-1 is a bifunctional cue, attracting some axons and repelling others …

Netrin-1 acts as a chemoattractant molecule to guide commissural neurons (CN) toward the
floor plate by interacting with the receptor deleted in colorectal cancer (DCC). The molecular …

Netrins are secreted proteins that regulate axon guidance and neuronal migration. Deleted
in colorectal cancer (DCC) is a well-established netrin-1 receptor mediating attractive …

During nervous system development, spinal commissural axons project toward floor plate
cells and trochlear motor axons extend away from these cells. Netrin-1, a diffusible protein …

The formation of precise connections between neurons and their targets during
development is dependent on extracellular guidance cues that allow growing axons to …