Emerging roles of ferroptosis in pulmonary fibrosis: current perspectives, opportunities and challenges

Y Hu, Y Huang, L Zong, J Lin, X Liu, S Ning - Cell Death Discovery, 2024 - nature.com
Pulmonary fibrosis (PF) is a chronic interstitial lung disorder characterized by abnormal
myofibroblast activation, accumulation of extracellular matrix (ECM), and thickening of …

Ferroptosis in pulmonary fibrosis: an emerging therapeutic target

C Wang, S Hua, L Song - Frontiers in Physiology, 2023 - frontiersin.org
In recent years, the role of ferroptosis in pulmonary fibrosis has garnered increasing interest
as a potential therapeutic target. Pulmonary fibrosis is a pathological process characterized …

Role of ferroptosis in regulating the epithelial–mesenchymal transition in pulmonary fibrosis

H Ling, H Xiao, T Luo, H Lin, J Deng - Biomedicines, 2023 - mdpi.com
Idiopathic pulmonary fibrosis is a chronic interstitial lung disease whose pathogenesis
involves a complex interaction of cell types and signaling pathways. Lung epithelial cells …

Multifaceted roles of ferroptosis in lung diseases

Y Li, Y Yang, Y Yang - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Ferroptosis is a distinct type of programmed cell death (PCD) that depends on iron and is
characterized by the accumulation of intracellular iron, exhaustion of glutathione …

Recent progress of ferroptosis in lung diseases

S Yu, J Jia, J Zheng, Y Zhou, D Jia… - Frontiers in cell and …, 2021 - frontiersin.org
Ferroptosis is a new form of programmed cell death due to iron-dependent excess
accumulation of lipid peroxides and differs from other programmed cell deaths in …

Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis‐Associated Mechanisms

TL Ma, Y Zhou, C Wang, L Wang… - Oxidative medicine …, 2021 - Wiley Online Library
Ferroptosis is an iron‐dependent regulated necrosis characterized by the peroxidation
damage of lipid molecular containing unsaturated fatty acid long chain on the cell …

Role of ferroptosis in lung diseases

W Xu, H Deng, S Hu, Y Zhang, L Zheng… - Journal of …, 2021 - Taylor & Francis
Ferroptosis is a new type of programmed cell death characterized by intracellular iron
accumulation and lipid peroxidation that leads to oxidative stress and cell death. The …

Unraveling the Molecular Regulation of Ferroptosis in Respiratory Diseases

L Zhu, J Zhou, C Yu, L Gu, Q Wang, H Xu… - Journal of …, 2024 - Taylor & Francis
Ferroptosis, a type of programmed cell death that relies on iron, is distinct in terms of its
morphological, biochemical and genetic features. Unlike other forms of cell death, such as …

A deep insight into ferroptosis in lung disease: facts and perspectives

F Zhang, Y Xiang, Q Ma, E Guo, X Zeng - Frontiers in Oncology, 2024 - frontiersin.org
In the last decade, ferroptosis has received much attention from the scientific research
community. It differs from other modes of cell death at the morphological, biochemical, and …

Targeting ferroptosis as a vulnerability in pulmonary diseases

L Yang, L Cao, X Zhang, B Chu - Cell Death & Disease, 2022 - nature.com
Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative
phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) …