Contraception with RISUG® and functional reversal through DMSO and NaHCO3 in male rabbits

AS Ansari, A Badar, K Balasubramanian… - Asian journal of …, 2017 - journals.lww.com
The study aimed to evaluate reversal of short-and long-term vas occlusion with reversible
inhibition of sperm under guidance (RISUG) using dimethyl sulfoxide (DMSO) and sodium …

Relative suitability of DMSO and NaHCO3 for reversal of RISUG® induced long‐term contraception

AS Ansari, M Hussain, SR Khan, NK Lohiya - Andrology, 2016 - Wiley Online Library
Among the vas‐based methods on trial, reversible inhibition of sperm under guidance
(RISUG®), a co‐polymer of styrene and maleic anhydride is being projected as an effective …

Sperm characteristics and teratology in rats following vas deferens occlusion with RISUG and its reversal

NK Lohiya, R Suthar, A Khandelwal… - … journal of andrology, 2010 - Wiley Online Library
The functional success of the reversal of vas occlusion by styrene maleic anhydride
(RISUG), using the solvent vehicle, Dimethyl Sulphoxide (DMSO), has been investigated …

Toxicity and mutagenicity evaluation following RISUG contraception reversal in rats

AS Ansari, M Hussain, SR Khan… - International …, 2018 - journals.sagepub.com
Reestablishment of fertility, after a male contraceptive method, is of great concern. In this
context, RISUG (Reversible Inhibition of Sperm Under Guidance) has been evaluated for its …

Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeys

NK Lohiya, B Manivannan, PK Mishra, S Sriram… - Contraception, 2005 - Elsevier
A preclinical evaluation for reversal through a noninvasive approach following long-term vas
occlusion with styrene maleic anhydride (SMA) has been attempted in langur monkeys at …

Safety evaluation through genotoxicity and apoptotic markers following RISUG® induced contraception and its reversal in male rabbits

AS Ansari, A Badar, NK Lohiya - Reproductive Toxicology, 2018 - Elsevier
The safety evaluation following vas occlusion with RISUG® and its reversal with DMSO and
NaHCO 3, using genotoxicity tests and apoptotic marker assays, was carried out in rabbits …

Evaluation of genotoxicity in leukocytes and testis following intra-vasal contraception with RISUG and its reversal by DMSO and NaHCO3 in Wistar albino rats

AS Ansari, I Alam, M Hussain, SR Khan… - Reproductive Toxicology, 2013 - Elsevier
Evaluation of genotoxicity of RISUG®–a vas based contraceptive, was carried out in the
present study. Animals were allotted into groups of sham operated control, vas occlusion …

RISUG® as a male contraceptive: journey from bench to bedside

B Khilwani, A Badar, AS Ansari, NK Lohiya - Basic and Clinical Andrology, 2020 - Springer
Even after decades of research men still lack reliable and reversible contraceptive methods
comparable to female methods of contraception. Traditional methods of male contraception …

Intravasal contraception with styrene maleic anhydride and its noninvasive reversal in langur monkeys (Presbytis entellus entellus)

NK Lohiya, B Manivannan, PK Mishra, N Pathak… - Contraception, 1998 - Elsevier
In male langurs with azoospermia induced by vas occlusion with styrene maleic anhydride
(SMA), the exploratory feasibility of azoospermia reversal by a new noninvasive reversal …

Rapid disappearance of spermatozoa after vasal occlusion in the dog

JD Schiff, PS Li, PN Schlegel… - Journal of …, 2003 - Wiley Online Library
The reproductive system of the male dog is unusual in that the seminal vesicles and
bulbourethral glands are absent. Therefore, we chose the dog as a model to evaluate the …