Brain infection by the fungus Cryptococcus neoformans results in inflammation of the
meninges and brain parenchyma, a condition known as meningoencephalitis. One million …

In patients with recognizable disease, the symptoms of pulmonary cryptococcosis may be
mild and are typically chronic. It is likely that both reactivation of previous infection and …

Cryptococcosis is a potentially lethal disease caused by fungal pathogens including
Cryptococcus neoformans and Cryptococcus gattii species complex. These fungal …

Cryptococcosis occurs most frequently in immunocompromised individuals. This has led to
the prevailing view that this disease is the result of weak immune responses that cannot …

Cryptococcus is predominantly an AIDS‐related pathogen that causes significant morbidity
and mortality in immunocompromised patients. Research studies have historically focused …

The fungal genus Cryptococcus comprises a group of pathogens with considerable
phenotypic and genotypic diversity that can lead to cryptococcosis in both healthy and …

Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

Cryptococcus is a ubiquitous environmental fungus and frequent colonizer of human lungs.
Colonization can lead to diverse outcomes, from clearance to long-term colonization to life …

The role of B cells and antibody-mediated immunity (AMI) is poorly understood regarding
infections with the encapsulated yeast species, Cryptococcus. Human cryptococcal disease …

Numerous virulence factors expressed by Cryptococcus neoformans modulate host
defenses by promoting nonprotective Th2-biased adaptive immune responses. Prior studies …