Cancers express tumor-associated antigens that should elicit immune response to
antagonize the tumor growth, but spontaneous immune rejection of established cancer is …

Over the past decade, there has been an accelerated understanding of immune regulatory
mechanisms. Peripheral immune regulation is linked to a collection of specialized regulatory …

The adaptive immune system is modulated by an important subset of CD4+ T lymphocytes
called Treg cells that function in maintaining immune homeostasis by preventing excessive …

Treg play a central role in maintenance of self tolerance and homeostasis through
suppression of self-reactive T cell populations. In addition to that role, Treg also survey …

Abstract Purpose: Regulatory T (Treg) cells expressing the transcription factor FOXP3 are
essential for the maintenance of immunologic self-tolerance but play a detrimental role in …

T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and
tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent …

Decades of advancements in immuno-oncology have enabled the development of current
immunotherapies, which provide long-term treatment responses in certain metastatic cancer …

Human regulatory T cells (Tregs) are crucial regulators of tissue repair, autoimmune
diseases, and cancer. However, it is challenging to inhibit the suppressive function of Tregs …

Tregs have a role in immunological tolerance and immune homeostasis by suppressing
immune reactions, and its therapeutic potential is critical in autoimmune diseases and …

At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …