Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer
E Timperi, I Pacella, V Schinzari, C Focaccetti… - …, 2016 - Taylor & Francis
Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally,
in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling …
in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling …
Tumor regulatory T cells potently abrogate antitumor immunity
Z Liu, JH Kim, LD Falo, Z You - The Journal of Immunology, 2009 - journals.aai.org
Regulatory T cell (Treg) from mice bearing a breast tumor were elevated (tumor Treg). In
vitro, whereas tumor Treg ability to inhibit tumor-primed CD4+ T cell activity is comparable to …
vitro, whereas tumor Treg ability to inhibit tumor-primed CD4+ T cell activity is comparable to …
[HTML][HTML] Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
H Van Damme, B Dombrecht, M Kiss… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid
approaches in antitumor immunotherapy but suffer from severe adverse effects due to their …
approaches in antitumor immunotherapy but suffer from severe adverse effects due to their …
Induced and natural regulatory T cells in human cancer
TL Whiteside, P Schuler, B Schilling - Expert opinion on biological …, 2012 - Taylor & Francis
Introduction: Evidence suggests that FOXP3+ CD25highCD4+ regulatory T cells (Treg)
which accumulate in cancer may have beneficial or unfavorable effects on prognosis. The …
which accumulate in cancer may have beneficial or unfavorable effects on prognosis. The …
Colorectal cancer-infiltrating regulatory T cells: functional heterogeneity, metabolic adaptation, and therapeutic targeting
S Aristin Revilla, O Kranenburg, PJ Coffer - Frontiers in immunology, 2022 - frontiersin.org
Colorectal cancer (CRC) is a heterogeneous disease with one of the highest rates of
incidence and mortality among cancers worldwide. Understanding the CRC tumor …
incidence and mortality among cancers worldwide. Understanding the CRC tumor …
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells
Understanding the relationship between tumor and peripheral immune environments could
allow longitudinal immune monitoring in cancer. Here, we examined whether T cells that …
allow longitudinal immune monitoring in cancer. Here, we examined whether T cells that …
What are regulatory T cells (Treg) regulating in cancer and why?
TL Whiteside - Seminars in cancer biology, 2012 - Elsevier
The role regulatory T cells (Treg) play in cancer development and progression is not clear.
Earlier evidence suggested that CD4+ FOXP3+ CD25high Treg accumulate in tumors and …
Earlier evidence suggested that CD4+ FOXP3+ CD25high Treg accumulate in tumors and …
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
C Li, P Jiang, S Wei, X Xu, J Wang - Molecular cancer, 2020 - Springer
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
CD4+ CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model
KG Elpek, C Lacelle, NP Singh, ES Yolcu… - The Journal of …, 2007 - journals.aai.org
Tumors use a complex set of direct and indirect mechanisms to evade the immune system.
Naturally arising CD4+ CD25+ FoxP3+ T regulatory (Treg) cells have been implicated …
Naturally arising CD4+ CD25+ FoxP3+ T regulatory (Treg) cells have been implicated …
Tissue regulatory T cells: regulatory chameleons
AR Muñoz-Rojas, D Mathis - Nature Reviews Immunology, 2021 - nature.com
Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …