The role regulatory T cells (Treg) play in cancer development and progression is not clear.
Earlier evidence suggested that CD4+ FOXP3+ CD25high Treg accumulate in tumors and …

Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …

Tumors use a complex set of direct and indirect mechanisms to evade the immune system.
Naturally arising CD4+ CD25+ FoxP3+ T regulatory (Treg) cells have been implicated …

Abstract Regulatory CD4+ T cells (Treg) prevent tumor clearance by conventional T cells
(Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the …

Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …

Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors,
although little is known about their role in restraining immunosurveillance during …

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of
immunotherapies and the prediction of their clinical responses in cancers. Here, we perform …

Tumor-infiltrating neoantigen-reactive T cells can mediate regression of metastatic
gastrointestinal cancers yet remain poorly characterized. We performed immunological …

Regulatory T (Treg) cells play crucial roles in health and disease through their
immunosuppressive properties against various immune cells. In this review we will focus on …

Several solid malignancies trigger lymphangiogenesis, facilitating metastasis. Tumor-
associated lymphatic vessels significantly contribute to the generation of an …