This case illustrates well the fact that antihypertensive therapy does not significantly reduce
the risk of acute myocardial infarction, nor does it necessarily lead to regression of left …

Background: The renin-angiotensin system is both a circulating and a local tissue hormonal
system. All components of the renin-angiotensin system have been found in important …

The effects of the angiotensin II receptor type 1 (AT1) antagonist losartan on pressure
overload-induced left ventricular (LV) hypertrophy were studied in female Sprague–Dawley …

The extracellular matrix of the myocardium contains an elaborate structural matrix composed
mainly of fibrillar types I and III collagen. This matrix is responsible for the support and …

Hypertension produces myocyte hypertrophy and increases the extracellular matrix. In order
to determine the composition of the extracellular matrix we studied the hearts from 14 …

The circulating renin-angiotensin system (RAS) plays an important role in the maintenance
of cardiovascular homeostasis. It has recently been demonstrated that endogenous RAS …

This article examines available data concerning the hypothesis that the renin-angiotensin
system directly stimulates cardiac hypertrophy and dysfunction in hypertension. Several …

A wound healing response that eventuates in fibrous tissue formation appears at the site of
myocardial infarction (MI). Fibrosis can also appear remote to the MI where it can cause an …

Abstract Philipps University of Marburg, Marburg, Germany According to the Framingham
Study, arterial hypertension and coronary artery disease are the major etiologic factors in the …

Objective: Myocardial fibrosis is an important determinant of pathological hypertrophy. In two
experimental models of arterial hypertension the purpose of the study was (a) to determine …