Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Histone methylation status is an important process associated with cell growth, survival,
differentiation and gene expression in human diseases. As a member of the KDM4 family …

KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …

Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …

The histone lysine demethylase 4 (KDM4) family plays an important role in regulating gene
transcription, DNA repair, and metabolism. The dysregulation of KDM4 functions is …

Epigenetic enzyme-targeted therapy is a promising new development in the field of drug
discovery. To date, histone deacetylases and DNA methyltransferases have been …

Histone lysine demethylation modification is a critical epigenetic modification. Lysine
demethylase 2A (KDM2A), a Jumonji C domain‑containing demethylase, demethylates the …

Histone demethylation is a vital process in epigenetic regulation of gene expression. A
number of histone demethylases are present to control the methylated states of histone …

There is growing evidence for a causal role of the KDM5 family of histone demethylases in
human cancer. In particular, KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) …