The purpose of this study was to evaluate the disposition kinetics of digoxin after the
administration of a single intravenous dose to the same dogs before and during azotemia …

A physiologically based pharmacokinetic model for digoxin disposition developed in the rat
was modified to account for the interspecies differences in tissue-to-plasma digoxin …

ABSTRACT OCHS, HERMANN R., GUNTHER BODEM, GERD BALES, DAVID J.
GREENBLATT AND THOMAS W. SMITH: Increased clearance of digoxin in rabbits during …

ABSTRACT Gibson, Thomas P. and Antonio P. Quintanilla: The renal clearance of digoxin is
dependent upon the serum digoxin concentration. J. Pharmacol. Exp. Ther. 21 5: 681-684 …

Digoxin doses of 14.3, 5.72 or 1.43 mcg/kg were administered to 8 cats and the plasma
digoxin concentrations (concns) were measured as a function of time for 96 hr …

Normal subjects were given 0.75 mg of intravenous digoxin as a bolus and a 1-hr infusion,
Radio-immunoassayed serum concentrations obtained over 48 hr and urinary excretion …

Nine healthy men received 0.5, 1.0, and 1.5 mg digoxin intravenously in random sequence
on occasions separated by at least 4 wk. Digoxin concentrations were measured in serum …

Digoxin bioavailability was studied in 6 normal volunteers during chronic dosing. The
absorption of digoxin was estimated by:(1) steady‐state serum dtgoxin levels;(2) the area …

The kinetics of digoxin have been investigated in healthy volunteers using an isotopic tracer
technique. A three compartment open kinetic model has been proposed as the simplest …

The purposes of this investigation were to demonstrate how computer simulations may be
employed to extrapolate data obtained from a single intravenous digoxin dose to multiple …