Adipose tissue, obesity and adipokines: role in cancer promotion

A Booth, A Magnuson, J Fouts… - … molecular biology and …, 2015 - degruyter.com
Adipose tissue is a complex organ with endocrine, metabolic and immune regulatory roles.
Adipose depots have been characterized to release several adipocytokines that work locally …

Obesity and cancer: the role of dysfunctional adipose tissue

RCM Van Kruijsdijk, E Van Der Wall… - … , biomarkers & prevention, 2009 - AACR
Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …

Obesity, adipokines and cancer: an update

CH Lee, YC Woo, Y Wang, CY Yeung… - Clinical …, 2015 - Wiley Online Library
Obesity causes dysfunction of adipose tissue, with resultant chronic inflammation and
adverse interplay of various adipokines, sex steroids and endocrine hormones. All these …

Update on adipose tissue and cancer

KA Brown, PE Scherer - Endocrine reviews, 2023 - academic.oup.com
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

Paracrine and endocrine effects of adipose tissue on cancer development and progression

J Park, DM Euhus, PE Scherer - Endocrine reviews, 2011 - academic.oup.com
The past few years have provided substantial evidence for the vital role of the local tumor
microenvironment for various aspects of tumor progression. With obesity and its …

Adipocytes: impact on tumor growth and potential sites for therapeutic intervention

S Hefetz-Sela, PE Scherer - Pharmacology & therapeutics, 2013 - Elsevier
The prevalence of obesity has increased dramatically in recent decades, reaching epidemic
proportions. It is becoming clear that obesity is associated not only with type 2 diabetes …

[HTML][HTML] Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

R Divella, R De Luca, I Abbate, E Naglieri… - Journal of …, 2016 - ncbi.nlm.nih.gov
Adipose tissue in addition to its ability to keep lipids is now recognized as a real organ with
both metabolic and endocrine functions. Recent studies demonstrated that in obese animals …

Classic and novel adipocytokines at the intersection of obesity and cancer: diagnostic and therapeutic strategies

N Spyrou, KI Avgerinos, CS Mantzoros… - Current obesity …, 2018 - Springer
Abstract Purpose of Review In this review, we investigate the role of classic and novel
adipocytokines in cancer pathogenesis synopsizing the mechanisms underlying the …

Tumor metabolic reprogramming by adipokines as a critical driver of obesity-associated cancer progression

DV Pham, PH Park - International journal of molecular sciences, 2021 - mdpi.com
Adiposity is associated with an increased risk of various types of carcinoma. One of the
plausible mechanisms underlying the tumor-promoting role of obesity is an aberrant …

Insights into the link between obesity and cancer

SE Ackerman, OA Blackburn, F Marchildon… - Current obesity …, 2017 - Springer
Abstract Purpose of Review Adipocytes have adapted to store energy in the form of lipid and
also secrete circulating factors called adipokines that signal to other tissues to coordinate …