Gut microbiota as an epigenetic regulator: pilot study based on whole-genome methylation analysis

H Kumar, R Lund, A Laiho, K Lundelin, RE Ley… - MBio, 2014 - Am Soc Microbiol
The core human gut microbiota contributes to the developmental origin of diseases by
modifying metabolic pathways. To evaluate the predominant microbiota as an epigenetic …

Gut microbiota composition is associated with the global DNA methylation pattern in obesity

B Ramos-Molina, L Sánchez-Alcoholado… - Frontiers in …, 2019 - frontiersin.org
Objective: Obesity and obesity-related metabolic diseases are characterized by gut
microbiota and epigenetic alterations. Recent insight has suggested the existence of a …

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development

WH Pan, F Sommer, M Falk-Paulsen, T Ulas, P Best… - Genome medicine, 2018 - Springer
Background The interplay of epigenetic processes and the intestinal microbiota may play an
important role in intestinal development and homeostasis. Previous studies have …

Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes

W Guo, Z Zhang, L Li, X Liang, Y Wu, X Wang… - Pharmacological …, 2022 - Elsevier
Obesity-prone (OP) individuals have a significant predisposition to obesity and diabetes.
Previously, we have found that OP individuals, despite being normal in weight and BMI …

Influences of the gut microbiota on DNA methylation and histone modification

J Ye, W Wu, Y Li, L Li - Digestive diseases and sciences, 2017 - Springer
The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian
gastrointestinal tract that can impact physiologic and pathologic processes. However, our …

Epigenetic regulation at the interplay between gut microbiota and host metabolism

J Miro-Blanch, O Yanes - Frontiers in genetics, 2019 - frontiersin.org
Gut microbiota communities have coevolved for millions of years in a symbiotic relationship
with their mammalian hosts. Elucidating and understanding the molecular mechanisms by …

Dissecting the interplay mechanism between epigenetics and gut microbiota: health maintenance and disease prevention

Y Wu, CZ Wang, JY Wan, H Yao, CS Yuan - International Journal of …, 2021 - mdpi.com
The gut microbiota exists throughout the full life cycle of the human body, and it has been
proven to have extensive impacts on health and disease. Accumulating evidence …

The epigenetic connection between the gut microbiome in obesity and diabetes

M Sharma, Y Li, ML Stoll, TO Tollefsbol - Frontiers in genetics, 2020 - frontiersin.org
Metabolic diseases are becoming an alarming health issue due to elevated incidences of
these diseases over the past few decades. Various environmental factors are associated …

The gut microbiota and their metabolites: potential implications for the host epigenome

M Mischke, T Plösch - Microbiota of the human body: implications in health …, 2016 - Springer
The gut microbiota represents a metabolically active biomass of up to 2 kg in adult humans.
Microbiota-derived molecules significantly contribute to the host metabolism. Large amounts …

Gut microbiota as important mediator between diet and DNA methylation and histone modifications in the host

P D'Aquila, L Lynn Carelli, F De Rango, G Passarino… - Nutrients, 2020 - mdpi.com
The human gut microbiota is a complex ecosystem consisting of trillions of microorganisms
that inhabit symbiotically on and in the human intestine. They carry out, through the …