The multifactorial nature of Alzheimer's disease for developing potential therapeutics
M Carmo Carreiras, E Mendes… - Current topics in …, 2013 - ingentaconnect.com
Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …
Multiple targets for the management of Alzheimer's disease
S Sayeed Ahmad, S Akhtar… - CNS & Neurological …, 2016 - ingentaconnect.com
AD is a progressive and irreversible neurodegenerative disease and the most common
cause of dementia in the elderly population. eta-amyloid cascade formation along with …
cause of dementia in the elderly population. eta-amyloid cascade formation along with …
Hybrids: a new paradigm to treat Alzheimer's disease
Alzheimer's disease (AD) is a complex neurodegenerative condition with several target
proteins contributing to its etiology. With 35.6 million cases worldwide documented in 2011 …
proteins contributing to its etiology. With 35.6 million cases worldwide documented in 2011 …
[HTML][HTML] Review on anti-alzheimer drug development: approaches, challenges and perspectives
AE Abdallah - RSC advances, 2024 - pubs.rsc.org
Alzheimer is an irreversible progressive neurodegenerative disease that causes failure of
cerebral neurons and disability of the affected person to practice normal daily life activities …
cerebral neurons and disability of the affected person to practice normal daily life activities …
Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease
A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …
continuous growing amount of papers and reviews, reflecting the important efforts made by …
New approaches to treating Alzheimer's disease
To date, no truly efficacious drugs for Alzheimer's disease (AD) have been developed;
moreover, all new anti-AD drugs developed since 2003 have failed. To succeed where …
moreover, all new anti-AD drugs developed since 2003 have failed. To succeed where …
Alzheimer's disease: current therapeutic approaches
V John, I Lieberburg, ED Thorsett - Annual Reports in Medicinal Chemistry, 1993 - Elsevier
Publisher Summary This chapter discusses the status of the active Alzheimer's disease (AD)
therapeutic approaches as well as some areas that are only beginning to see medicinal …
therapeutic approaches as well as some areas that are only beginning to see medicinal …
Recent developments in natural and synthetic drug research for Alzheimer's disease
Alzheimer's Disease (AD) is a progressive and degenerative neurological disorder
characterized by loss of cognition and memory. However, the pathogenesis of AD is still not …
characterized by loss of cognition and memory. However, the pathogenesis of AD is still not …
[HTML][HTML] New treatment strategies for Alzheimer's disease: is there a hope?
I Aprahamian, F Stella, OV Forlenza - Indian Journal of Medical …, 2013 - journals.lww.com
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, and
corresponds to the most common cause of dementia worldwide. Although not fully …
corresponds to the most common cause of dementia worldwide. Although not fully …
[HTML][HTML] Symptomatic and disease-modifying therapy pipeline for Alzheimer's disease: Towards a personalized polypharmacology patient-centered approach
Since 1906, when Dr. Alois Alzheimer first described in a patient “a peculiar severe disease
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …