The multifactorial nature of Alzheimer's disease for developing potential therapeutics

M Carmo Carreiras, E Mendes… - Current topics in …, 2013 - ingentaconnect.com
Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Multiple targets for the management of Alzheimer's disease

S Sayeed Ahmad, S Akhtar… - CNS & Neurological …, 2016 - ingentaconnect.com
AD is a progressive and irreversible neurodegenerative disease and the most common
cause of dementia in the elderly population. eta-amyloid cascade formation along with …

Hybrids: a new paradigm to treat Alzheimer's disease

M Singh, M Kaur, N Chadha, O Silakari - Molecular diversity, 2016 - Springer
Alzheimer's disease (AD) is a complex neurodegenerative condition with several target
proteins contributing to its etiology. With 35.6 million cases worldwide documented in 2011 …

[HTML][HTML] Review on anti-alzheimer drug development: approaches, challenges and perspectives

AE Abdallah - RSC advances, 2024 - pubs.rsc.org
Alzheimer is an irreversible progressive neurodegenerative disease that causes failure of
cerebral neurons and disability of the affected person to practice normal daily life activities …

Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease

A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …

New approaches to treating Alzheimer's disease

H Zheng, M Fridkin, M Youdim - Perspectives in medicinal …, 2015 - journals.sagepub.com
To date, no truly efficacious drugs for Alzheimer's disease (AD) have been developed;
moreover, all new anti-AD drugs developed since 2003 have failed. To succeed where …

Alzheimer's disease: current therapeutic approaches

V John, I Lieberburg, ED Thorsett - Annual Reports in Medicinal Chemistry, 1993 - Elsevier
Publisher Summary This chapter discusses the status of the active Alzheimer's disease (AD)
therapeutic approaches as well as some areas that are only beginning to see medicinal …

Recent developments in natural and synthetic drug research for Alzheimer's disease

G Orhan, I Orhan, B Sener - Letters in Drug Design & Discovery, 2006 - ingentaconnect.com
Alzheimer's Disease (AD) is a progressive and degenerative neurological disorder
characterized by loss of cognition and memory. However, the pathogenesis of AD is still not …

[HTML][HTML] New treatment strategies for Alzheimer's disease: is there a hope?

I Aprahamian, F Stella, OV Forlenza - Indian Journal of Medical …, 2013 - journals.lww.com
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, and
corresponds to the most common cause of dementia worldwide. Although not fully …

[HTML][HTML] Symptomatic and disease-modifying therapy pipeline for Alzheimer's disease: Towards a personalized polypharmacology patient-centered approach

X Morató, V Pytel, S Jofresa, A Ruiz… - International Journal of …, 2022 - mdpi.com
Since 1906, when Dr. Alois Alzheimer first described in a patient “a peculiar severe disease
process of the cerebral cortex”, people suffering from this pathology have been waiting for a …