How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage,
and stromal development from a population of highly pure, postnatal skeletal stem cells …

Skeletal stem and progenitor cell populations are crucial for bone physiology.
Characterization of these cell types remains restricted to heterogenous bulk populations with …

Stem cell regulation and hierarchical organization of human skeletal progenitors remain
largely unexplored. Here, we report the isolation of a self-renewing and multipotent human …

Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage,
bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays …

There are limited methods available to study skeletal stem, progenitor, and progeny cell
activity in normal and diseased contexts. Most protocols for skeletal stem cell isolation are …

Organs are composites of tissue types with diverse developmental origins, and they rely on
distinct stem and progenitor cells to meet physiological demands for cellular production and …

Human skeletal stem cells (hSSCs) hold tremendous therapeutic potential for developing
new clinical strategies to effectively combat congenital and age-related musculoskeletal …

Bone-related maladies are a major health burden on modern society. Loss of skeletal
integrity and regeneration capacity through aging, obesity, and disease follows from a …

Multipotent mesenchymal stromal cells (MSCs) are required for skeletal formation,
maintenance, and repair throughout life; however, current models posit that postnatally …

The tissue-resident skeletal stem cells (SSCs), which are self-renewal and multipotent,
continuously provide cells (including chondrocytes, bone cells, marrow adipocytes, and …