[HTML][HTML] Molecular characterization of acute myeloid leukemia

K Döhner, H Döhner - Haematologica, 2008 - haematologica.org
Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized
by the accumulation of acquired somatic genetic alterations in hematopoietic progenitor …

Acute myeloid leukaemia

A Khwaja, M Bjorkholm, RE Gale, RL Levine… - Nature reviews Disease …, 2016 - nature.com
Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived
from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of …

[HTML][HTML] Molecular genetic markers in acute myeloid leukemia

S Yohe - Journal of clinical medicine, 2015 - mdpi.com
Genetics play an increasingly important role in the risk stratification and management of
acute myeloid leukemia (AML) patients. Traditionally, AML classification and risk …

[HTML][HTML] Acute myeloid leukemia—genetic alterations and their clinical prognosis

FA Lagunas-Rangel, V Chávez-Valencia… - … journal of hematology …, 2017 - ncbi.nlm.nih.gov
Acute myeloid leukemia (AML) is a group of hematological diseases, phenotypic and
genetically heterogeneous, characterized by abnormal accumulation of blast cells in the …

The evolving molecular genetic landscape in acute myeloid leukaemia

MA Sanders, PJM Valk - Current opinion in hematology, 2013 - journals.lww.com
The list of acquired mutations with clinical value in AML is growing. Clinical implementation
of this multitude of markers will require integrated approaches and selection of markers to …

How I investigate acute myeloid leukemia

D Narayanan, OK Weinberg - International journal of laboratory …, 2020 - Wiley Online Library
Acute myeloid leukemia (AML) is a neoplasm of immature myeloid cells and is associated
with a wide variety of clinical presentations, morphological features, immunophenotypes …

Advances in understanding the biology and genetics of acute myelocytic leukemia

SB McKenzie - American Society for Clinical Laboratory Science, 2005 - clsjournal.ascls.org
Acute myelocytic leukemia (AML) is a malignant neoplasm of hematopoietic cells
characterized by an abnormal proliferation of myeloid precursor cells, decreased rate of self …

Genetic characterization and risk stratification of acute myeloid leukemia

F Pourrajab, MR Zare-Khormizi… - Cancer management …, 2020 - Taylor & Francis
The most common acute leukemia in adults is acute myeloid leukemia (AML). The
pathophysiology of the disease associates with cytogenetic abnormalities, gene mutations …

Genetic abnormalities and challenges in the treatment of acute myeloid leukemia

CC Kumar - Genes & cancer, 2011 - journals.sagepub.com
Acute myeloid leukemia (AML) is a hematopoietic disorder in which there are too many
immature blood-forming cells accumulating in the bone marrow and interfering with the …

[HTML][HTML] The clinical impact of the molecular landscape of acute myeloid leukemia

S Kayser, MJ Levis - Haematologica, 2023 - ncbi.nlm.nih.gov
Research into the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has
led to remarkable advances in our understanding of the disease. Mutations now allow us to …