Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints
resulting from the age-associated loss of cartilage. Well-powered genetic studies have …

Objective Osteoarthritis (OA) is polygenic with over 90 independent genome-wide
association loci so far reported. A key next step is the identification of target genes and the …

Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Osteoarthritis (OA) is a prevalent disease of articular joints and primarily characterized by
degradation and calcification of articular cartilage. Presently, no effective treatment other …

Objective To identify osteoarthritis (OA) progression–modulating pathways in articular
cartilage and their respective regulatory epigenetic and genetic determinants in end‐stage …

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of
cartilage within articular joints. Although it is a leading cause of disability, there are no …

Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …

The development of osteoarthritis (OA) depends on genetic and environmental factors,
which influence the biology of the chondrocyte via epigenetic regulation. Changes within the …

Objectives Transcriptional changes in cartilage can impact function by causing degradation
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …