In 2002, Al-Tassan and co-workers described for the first time a recessive form of inherited
polyposis associated with germline mutations of MUTYH, a gene encoding a base excision …

MUTYH gene is involved in the base excision repair (BER) mechanism and its pathogenic
alterations are associated with colorectal polyposis and cancer. MUTYH-associated …

Established predisposition genes account for only a small proportion of familial colorectal
cancer. Recently, it has been shown that germline mutations in MUTYH predispose to …

MUTYH-associated polyposis (MAP) was first described in 2002. MUTYH is a component of
a base excision repair system that protects the genomic information from oxidative damage …

MUTYH‐associated polyposis (MAP) is a colorectal cancer syndrome, due to biallelic
mutations of MUTYH. This Base Excision Repair gene encodes for a DNA glycosylase that …

MUTYH is a base excision repair enzyme, it plays a crucial role in the correction of DNA
errors from guanine oxidation and may be considered a cell protective factor. In humans it is …

Biallelic germline mutations in the base excision repair enzyme gene MUTYH lead to
multiple colorectal adenomas and carcinomas referred to as MUTYH-associated polyposis …

BACKGROUND & AIMS: Biallelic mutations in the base excision DNA repair gene MUTYH
lead to MUTYH-associated polyposis (MAP) and predisposition to colorectal cancer (CRC) …

PURPOSE: MUTYH-associated polyposis syndrome is inherited as a recessive trait and is
characterized by the presence of colorectal adenomas and cancer predisposition. Carriers …

MUTYH-associated polyposis (MAP) is a rare hereditary condition caused by the biallelic
mutation in the MUTYH gene encoding MUTYH glycosylase. This enzyme is a key member …