There is a risk of exposure to drugs in neonates during the lactation period due to maternal
drug intake. The ability to predict drugs of potential hazards to the neonates would be useful …

Women commonly take medication during lactation. Currently, there is little information
about the exposure-related safety of maternal medicines for breastfed infants. The aim was …

Medication use during breastfeeding can be a matter of concern due to unintended infant
exposure to drugs through breast milk. The available information relating to the safety of …

Although most medications can be taken safely during breastfeeding, potential risks of infant
toxicity do exist because all medications will be excreted into the breast milk to some extent …

Physiologically based pharmacokinetic (PBPK) modelling is a bottom-up approach to predict
pharmacokinetics in specific populations based on population-specific and medicine …

The relative lack of information on medication use during breastfeeding is an ongoing
problem for health professionals and mothers alike. Most nursing mothers are prescribed …

Adverse effects in infants due to the ingestion of drugs and other xenobiotics remain an area
of concern. A key parameter in assessing infant exposure via breast milk, the milk to plasma …

Background: Successful practice of clinical perinatal pharmacology requires a thorough
understanding of the pronounced physiological changes during lactation and how these …

The unmet medical need of providing evidence‐based pharmacotherapy for pregnant
women is recognized by the regulatory bodies. Physiologically based pharmacokinetic …

Pregnancy and the postpartum period are associated with several physiological changes
that can alter the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs. For certain …