Following injury to a peripheral nerve, changes in the behavior of Schwann cells help to
define the subsequent microenvironment for regeneration. Such changes, however, have …

Peripheral nerve injury is followed by a wave of Schwann cell proliferation in the distal nerve
stumps. To resolve the role of Schwann cell proliferation during functional recovery of the …

Mammalian peripheral nerve fibres can regenerate after injury. Repair is most likely to
succeed if axons are simply crushed or have only a very short (< 0–5 cm) interstump gap to …

Functional recovery is poor after peripheral nerve injury and delayed surgical repair or when
nerves must regenerate over long distances to reinnervate distant targets. A reduced …

The characteristic response of Schwann cells (SC) accompanies peripheral nerve injury and
regeneration. To elucidate their role, the question of whether or not regenerating axons can …

Schwann cells are the glial cells of the peripheral nervous system (PNS) which both
myelinate and provide trophic support for their associated axons. Their functions are critical …

Proliferation of Schwann cells during nerve degeneration or regeneration is well
documented in vivo. We investigated whether the proliferative response of Schwann cells to …

Peripheral nerve injury (PNI) is common and, unlike damage to the central nervous system
injured nerves can effectively regenerate depending on the location and severity of injury …

Wallerian degeneration of the distal stump of a severed peripheral nerve involves invasion
by myelomonocytic cells, whose presence is necessary for destruction of myelin and for …

Changes in cytokine and chemokine expression during Wallerian degeneration have been
studied using nerve transection models, which result in denervation of both myelinating and …