New insights into PTEN
T Tamguney, D Stokoe - Journal of cell science, 2007 - journals.biologists.com
The functions ascribed to PTEN have become more diverse since its discovery as a putative
phosphatase mutated in many human tumors. Although it can dephosphorylate lipids and …
phosphatase mutated in many human tumors. Although it can dephosphorylate lipids and …
[HTML][HTML] PTEN: multiple functions in human malignant tumors
M Milella, I Falcone, F Conciatori, U Cesta Incani… - Frontiers in …, 2015 - frontiersin.org
PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
The role of PTEN signaling perturbations in cancer and in targeted therapy
M Keniry, R Parsons - Oncogene, 2008 - nature.com
The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
The functions and regulation of the PTEN tumour suppressor
MS Song, L Salmena, PP Pandolfi - Nature reviews Molecular cell …, 2012 - nature.com
The importance of the physiological function of phosphatase and tensin homologue (PTEN)
is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3 …
is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3 …
PTEN: from pathology to biology
ML Sulis, R Parsons - Trends in cell biology, 2003 - cell.com
The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …
importance in the development of cancer is probably underestimated. As the primary …
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis
KM Yamada, M Araki - Journal of cell science, 2001 - journals.biologists.com
PTEN (also known as MMAC-1 or TEP-1) is one of the most frequently mutated tumor
suppressors in human cancer. It is also essential for embryonic development. PTEN …
suppressors in human cancer. It is also essential for embryonic development. PTEN …
PTEN function: how normal cells control it and tumour cells lose it
NR Leslie, CP Downes - Biochemical Journal, 2004 - portlandpress.com
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
PTEN proteoforms in biology and disease
Proteoforms are specific molecular forms of protein products arising from a single gene that
possess different structures and different functions. Therefore, a single gene can produce a …
possess different structures and different functions. Therefore, a single gene can produce a …