The DNA sequences required for the expression of the rabbit β-globin gene in vivo have
been examined. A variety of mutant rabbit β-globin gene templates were linked to a simian …

We have studied the transcription in vitro of the rabbit/3-globin gene in the HeLa cell system.
Using cloned fragments of this gene, we obtained specific transcripts with 5'ends at the “cap” …

Mouse thymidine kinase-negative (TK-) L cells were transformed with concatenates of
cloned herpes simplex virus 1 TK DNA and different rabbit beta-globin DNAs in which the …

THE level of expression of exogenous genes carried by transgenic mice typically varies from
mouse to mouse and can be quite low. This behaviour is attributed to the influence of the …

We have performed a detailed analysis of DNA sequences in the− 80 region of the rabbit β-
globin gene that are required for transcription. A variety of rabbit β-globin gene templates …

The globin gene family represents an attractive system for the study of gene regulation
during mammalian development, as its expression is subject to both tissue-specific and …

We have transcribed various alpha-globin gene-containing templates by using a simplified
in vitro system and have shown that the 5'end of each of the RNA polymerase II-specific …

The human α-and β-globin genes have been activated in MEL× human fibroblast cell
hybrids. However, even though the human γ-and β-globin genes are closely linked and …

Summary Cloned rabbit/?-globin genes, modified in vitro by restructuring or site-directed
mutagenesis, were introduced into mouse 3T6 cells, and the resulting transcripts were …

Chemically induced differentiation of cultured murine erythroleukaemia (MEL) cells results in
a several hundred-fold increase hi transcription of the adult mouse globin genes1–3 and …