Mice lacking DARPP-32, a striatal-enriched phosphoprotein, show abnormal behavioral and
biochemical responses to cocaine, but the role of individual phosphorylation sites in DARPP …

The reinforcing effect of cocaine is associated with increases in dopamine in the striatum.
The phosphoprotein DARPP-32 (dopamine-and cAMP-regulated phosphoprotein) has been …

Drugs of abuse share the ability to enhance dopaminergic neurotransmission in the dorsal
and ventral striatum. The action of dopamine is modulated by additional neurotransmitters …

DARPP-32 is a dual-function protein kinase/phosphatase inhibitor that is involved in striatal
signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the …

Activation of the cAMP/PKA pathway in the dopaminoceptive neurons of the striatum has
been proposed to mediate the actions of various classes of drugs of abuse. Here, we show …

We investigated the role of the protein phosphatase inhibitor, dopamine‐and cAMP‐
regulated phosphoprotein of 32 kDa (DARPP‐32), in the expression of striatal …

The dopamine-and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), plays a key
role in dopaminoceptive neurons in the neostriatum (and likely in other brain regions) in …

BACKGROUND: The addictive properties of nicotine are mediated via dopaminergic
pathways and their post-synaptic neurons in the striatum. Because post-synaptic neurons …

Dopamine receptor signaling exhibits prominent plasticity that is important for the
pathogenesis of both addictive and movement disorders. Psychoactive stimulants that …

Background: Modulation of protein phosphorylation by dopamine is thought to play an
important role in drug reward. Protein phosphatase-1 (PP-1) is known to mediate some of …