Have you ever noticed the impact of images? As you pick up a textbook, read a paper, or
review a grant, have you noticed how your eye and mind quickly grasp and capture pictures …

The genesis for this Special Issue devoted to “3D Imaging in Lung Biology” emerged when
the two of us met for the first time as faculty at the Jackson Laboratory's course,“Phenotyping …

Respiratory ailments continue to pose a formidable challenge to public health. The
respiratory system is a delicate interplay of muscle contraction, pressure gradients and a …

Stereology is the method of choice for the quantitative assessment of biological objects in
microscopy. It takes into account the fact that, in traditional microscopy such as conventional …

Respiratory diseases are a major reason for death in both men and women worldwide. The
development of therapies for these diseases has been slow and the lack of relevant human …

Mouse models are important for pulmonary research to gain insight into structure and
function in normal and diseased states, thereby extending knowledge of human disease …

The airway tree in the human lung is built by branching morphogenesis from 4
postconceptional weeks (PCW) until 17 PCW. Here we study the entire airway tree in left …

The delicate structure of murine lungs poses many challenges for acquiring high-quality
images that truly represent the living lung. Here, we describe several optimized procedures …

Most medical imaging is inherently three-dimensional (3D) but for validation of pathological
findings, histopathology is commonly used and typically histopathology images are acquired …

Investigating the structure and function of pulmonary alveoli in vivo is crucial for
understanding the normal and diseased lung. In particular, understanding the three …