The apparent diffusion coefficients (ADCs) of hyperpolarized 3He and 129Xe gases were
measured in the lungs of rabbits with elastase-induced emphysema and correlated against …

Despite a long history of development, diagnostic tools for in vivo regional assessment of
lungs in patients with pulmonary emphysema are not yet readily available. Recently, a new …

Purpose To measure the apparent diffusion coefficient (ADC) of hyperpolarized (HP) 3He
gas using diffusion weighted MRI in healthy volunteers and patients with emphysema and …

MRI-based study of 3He gas diffusion in lungs may provide important information on lung
microstructure. Lung acinar airways can be described in terms of cylinders covered with …

Hyperpolarized noble gas (3He and 129Xe) apparent diffusion coefficient (ADC)
measurements have shown remarkable sensitivity to microstructural (ie, alveolar) changes …

The structure and integrity of pulmonary acinar airways and their changes in different
diseases are of great importance and interest to a broad range of physiologists and …

The study of lung emphysema dates back to the beginning of the 17th century. Nevertheless,
a number of important questions remain unanswered because a quantitative localized …

In this work, we investigate 3He magnetic resonance imaging as a noninvasive
morphometric tool to assess emphysematous disease state on a local level. Emphysema …

PURPOSE: To quantitatively evaluate hyperpolarized helium 3 (3He) diffusion magnetic
resonance (MR) images of the lung in patients with emphysema and to determine whether …

Purpose To characterize the effect of diffusion time on short‐range hyperpolarized 3He
magnetic resonance imaging (MRI) diffusion measurements across a wide range of …