New insights in endogenous modulation of ligand-gated ion channels: histamine is an inverse agonist at strychnine sensitive glycine receptors

O Kletke, OA Sergeeva, P Lorenz, S Oberland… - European journal of …, 2013 - Elsevier
Histamine is involved in many physiological functions in the periphery and is an important
neurotransmitter in the brain. It acts on metabotropic H1–H4 receptors mediating …

Histamine-gated ion channels in mammals?

MW Fleck, JL Thomson, LB Hough - Biochemical pharmacology, 2012 - Elsevier
There is ample pharmacological and physiological evidence for yet unidentified histamine
receptors in mammalian brain that are linked to a Cl− conductance. In invertebrates, two …

The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes

K Sahlholm, J Nilsson, D Marcellino, K Fuxe… - European journal of …, 2007 - Elsevier
The histamine H3 receptor mediates inhibitory responses in the nervous system. Here, we
demonstrate the coupling of the human histamine H3 receptor to G protein-coupled inward …

Identification and characterization of heptapeptide modulators of the glycine receptor

GL Cornelison, NC Pflanz, ME Tipps… - European journal of …, 2016 - Elsevier
The glycine receptor is a member of the Cys-loop receptor superfamily of ligand-gated ion
channels and is implicated as a possible therapeutic target for the treatment of diseases …

Cross‐linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation

IA Lobo, RA Harris, JR Trudell - Journal of neurochemistry, 2008 - Wiley Online Library
J. Neurochem.(2008) 104, 1649–1662. Abstract The glycine receptor is a member of the Cys‐
loop, ligand‐gated ion channel family and is responsible for inhibition in the CNS. We …

Electrophysiology-based analysis of human histamine H4 receptor pharmacology using GIRK channel coupling in Xenopus oocytes

K Sahlholm, J Nilsson, D Marcellino, K Fuxe… - European journal of …, 2008 - Elsevier
The recently cloned histamine H4 receptor is expressed predominantly in haematopoietic
cells and has been found to modulate the function of mast cells, eosinophils, dendritic cells …

Modulators of the inhibitory glycine receptor

U Breitinger, HG Breitinger - ACS Chemical Neuroscience, 2020 - ACS Publications
The inhibitory glycine receptor is a member of the Cys-loop superfamily of ligand-gated ion
channels. It is the principal mediator of rapid synaptic inhibition in the spinal cord and …

Glycine receptor mediated responses in rat histaminergic neurons

OA Sergeeva, KS Eriksson, HL Haas - Neuroscience letters, 2001 - Elsevier
Patch-clamp whole-cell recordings were made in the hypothalamic tuberomammillary (TM)
nucleus from isolated histaminergic neurons, identified by their expression of histidine …

[PDF][PDF] Histamine receptors

HL Haas, P Panula - Neuropharmacology, 2016 - helda.helsinki.fi
Histamine and its receptors in the nervous system received recognition late in comparison to
the other aminergic transmitters, after the detection of histaminergic neurons in the posterior …

[HTML][HTML] Identification of amino acids involved in histamine potentiation of GABAa receptors

U Thiel, SJ Platt, S Wolf, H Hatt… - Frontiers in …, 2015 - frontiersin.org
Histamine is a neurotransmitter involved in a number of physiological and neuronal
functions. In mammals, such as humans, and rodents, the histaminergic neurons found in …