Patients with cardiomyopathy often receive multiple medicines, including digitalis, diuretics,
antiarrhythmic agents, and vasodilators. Digitalis pharmacokinetics are altered by several of …

Numerous studies have been devoted to the effect of slow calcium channel inhibitors on
plasma digoxin concentrations. The principal drugs tested, verapamil and nifedipine, were …

Drug interactions with digoxin are important because of this agent's narrow therapeutic
index. Among the drugs that can decrease digoxin bioavailability are cholestyramine …

In clinical Arrhythmology it is often necessary to associate digitalis and antiarrhythmic
agents. This calls for study of possible interaction between the employed drugs. We found a …

Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the
pharmacokinetic basis of this interaction in 10 normal subjects. The pharmacokinetic …

Initial reports of the interaction between quinidine and digoxin have led to attempts to
delineate the various facets of this interaction, forced a reexamination of our understanding …

While preliminary screening for interactions between new cardiovascular
pharmacotherapeutic agents and digoxin can be efficiently and safely conducted in normal …

The digoxin-quinidine interaction was studied in nine healthy human subjects aged 26 to 31
years. A single oral dose (400 mg) of quinidine sulfate administered to subjects taking …

A variety of cardioactive agents have been shown to affect the pharmacokinetics of digoxin
and thereby alter serum digoxin levels. Since the first reports describing the digoxin …

In order to determine the interaction between diltiazem and digoxin, plasma digoxin
concentrations and the principal ECG parameters (24 hour Holter monitoring) were …