Abstract Chemokine (C-X3-C motif) ligand 1 (CX 3 CL1, also known as fractalkine) and its
receptor chemokine (C-X3-C motif) receptor 1 (CX 3 CR1) are widely expressed in immune …

Chronic infections promote the terminal differentiation (or" exhaustion") of T cells and are
thought to preclude the formation of memory T cells. In contrast, we discovered a small …

When naive T lymphocytes are activated and differentiate into memory/effector cells, they
down‐regulate receptors for constitutive chemokines such as CXCR4 and CCR7 and …

Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …

Functionally distinct T cell subsets exhibit specific chemokine receptor profiles that regulate
their tissue localization. Here, we show that human peripheral blood CD4+ and CD8+ …

Central memory CD8+ T cells (Tcm) control systemic secondary infections and can protect
from chronic infection and cancer as a result of their stem-cell-like capacity to expand …

CD16+ monocytes represent 5–10% of peripheral blood monocytes in normal individuals
and are dramatically expanded in several pathological conditions including sepsis, human …

CD8 T cells play a key role in host defense against intracellular pathogens. Efficient
migration of these cells into sites of infection is therefore intimately linked to their effector …

Translating studies on T cell function and modulation from mouse models to humans
requires extrapolating in vivo results on mouse T cell responses in lymphoid organs (spleen …

In chronic hepatitis C virus (HCV) infection, exhausted HCV-specific CD8+ T cells comprise
memory-like and terminally exhausted subsets. However, little is known about the molecular …