The factors and steps controlling postinfection CD8+ T cell terminal effector versus memory
differentiation are incompletely understood. Whereas we found that naive TCF7 (alias “Tcf …

Transition from naive to Ag-experienced effector/memory CD4+ T cells is initiated during
contact with APC in secondary lymphoid tissue. Here, we demonstrate that the CXCR5 is a …

Fractalkine/CX3C ligand 1 and its receptor CX3CR1 are known to mediate both cell
adhesion and cell migration. Here we show that CX3CR1 defines peripheral blood cytotoxic …

Recent in vitro and in vivo studies have shown that the chemokine fractalkine is widely
expressed in the brain and localized principally to neurons. Central nervous system …

The forkhead O transcription factors (FOXO) integrate a range of extracellular signals,
including growth factor signaling, inflammation, oxidative stress, and nutrient availability, to …

During chronic viral infection, CD8+ T cells develop into three major phenotypically and
functionally distinct subsets: Ly108+ TCF-1+ progenitors, Ly108− CX3CR1− terminally …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

Interactions between fractalkine (CX3CL1) and its receptor, CX3CR1, mediate leukocyte
adhesion, activation, and trafficking. The respiratory syncytial virus (RSV) G protein has a …

In response to acute infection, naive CD8+ T cells expand, differentiate into effector cells,
and then contract to a long-lived pool of memory cells after pathogen clearance. During …

Immunological memory and exhaustion are fundamental features of adaptive immunity.
Recent advances reveal increasing heterogeneity and diversity among CD8 T-cell subsets …