Obesity is a strong risk factor for the development of type 2 diabetes. We have previously
reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is …

The BTBR mouse strain harbors alleles promoting insulin resistance. When made
genetically obese (ob/ob), these mice develop severe type 2 diabetes (fasting glucose> 400 …

Insulin resistance occurs early in the disease process, preceding the development of type 2
diabetes. Therefore, the identification of molecules that contribute to insulin resistance and …

Objective To determine whether expression of transcription factors and lipogenic enzymes is
altered in liver and adipose tissue of mice with obesity, insulin resistance, and nonalcoholic …

Obesity is strongly correlated with type 2 diabetes mellitus, a common disorder of glucose
and lipid metabolism. Although adipocytes are critical in obesity, their role in diabetes has …

We have previously shown that C57BL/6J (B6) mice develop severe obesity and diabetes if
weaned onto high-fat diets, whereas A/J mice tend to be obesity and diabetes-resistant. The …

OBJECTIVE To identify metabolic derangements contributing to diabetes susceptibility in the
leptin receptor–deficient obese C57BLKS/J-db/db (BKS-db) mouse strain. RESEARCH …

Objective—Diabetic hypertriglyceridemia is thought to be primarily driven by increased
hepatic de novo lipogenesis. However, experiments in animal models indicated that insulin …

Susceptibility to obesity changes during the course of life. We utilized the C57 BL/6J (B6)
and 129S mouse as a genetic model for variation in diet‐induced obesity to define the …

It has been suggested that a genetic predisposition and an increased total fat mass,
particularly a specific increase in visceral fat, contribute to the metabolic aberrations …