Emerging protein targets for metal-based pharmaceutical agents: An update

A De Almeida, BL Oliveira, JDG Correia… - Coordination Chemistry …, 2013 - Elsevier
The peculiar chemical properties of metal-based drugs impart innovative pharmacological
profiles to this class of therapeutic and diagnostic agents, most likely in relation to novel …

Exploring the mechanisms of metalbased pharmacological agents via an integrated approach

A Casini - Journal of inorganic biochemistry, 2012 - Elsevier
The peculiar chemical properties of metal-based drugs impart innovative pharmacological
profiles to this class of therapeutic and diagnostic agents, most likely in relation to novel …

Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: Current frontiers and perspectives

M Wenzel, A Casini - Coordination Chemistry Reviews, 2017 - Elsevier
Metal-based compounds form a promising class of therapeutic agents, whose mechanisms
of action still need to be elucidated, and that are in general prone to undergo extensive …

Metal complexes in medicinal chemistry: new vistas and challenges in drug design

KH Thompson, C Orvig - Dalton transactions, 2006 - pubs.rsc.org
An overview is presented of selected metal-based pharmaceuticals, either diagnostic or
therapeutic, with emphasis on specific attributes and in vivo interactions of these compounds …

Advancement of metal compounds as therapeutic and diagnostic metallodrugs: Current frontiers and future perspectives

I Yousuf, M Bashir, F Arjmand, S Tabassum - Coordination Chemistry …, 2021 - Elsevier
Coordination compounds on account of distinctive features of metal ions that include
variable oxidation states, diverse range of geometries and coordination numbers …

Metalloproteomics for unveiling the mechanism of action of metallodrugs

Y Wang, H Li, H Sun - Inorganic chemistry, 2019 - ACS Publications
The clinical application and development of potent metal-based drugs relies heavily on a full
understanding of their underlying molecular mechanisms. The emerging research field of …

Medicinal inorganic chemistry: An updated review on the status of metallodrugs and prominent metallodrug candidates

VM Miranda - Reviews in Inorganic Chemistry, 2022 - degruyter.com
Metallodrugs correspond to a small portion of all available drugs in the market and, yet,
some of them are among the most used and important drugs in modern medicine. However …

Organometallic complexes: new tools for chemotherapy

N Chavain, C Biot - Current medicinal chemistry, 2010 - ingentaconnect.com
The importance of organometallics can be noticed by their presence in all life organisms.
The most known natural organometallic molecule is vitamin B12, a porphyrin containing a …

Multifunctional ligands in medicinal inorganic chemistry-current trends and future directions

L Chiang, MR Jones, SL Ferreira… - Current Topics in …, 2012 - ingentaconnect.com
This review will highlight recent advances in ligand design for innovative applications in
medicinal inorganic chemistry. Ligands that effectively bind metal ions and also include …

[HTML][HTML] Metal complexes in diagnosis and therapy

D Tesauro - International Journal of Molecular Sciences, 2022 - mdpi.com
The use of metal complexes for health and healing has been in use for over the last several
millennia and perhaps longer. Transition metals have a long history as antibacterials and …