Abstract The sigma-2 receptor (S2R) is a potential therapeutic target for cancer and
neuronal diseases. However, the identity of the S2R has remained a matter of debate …

A controversial relationship between sigma-2 and progesterone receptor membrane
component 1 (PGRMC1) proteins, both representing promising targets for the therapy and …

The sigma-2 receptor, whose gene remains to be cloned, has been validated as a biomarker
for tumour cell proliferation. Here we report the use of a novel photoaffinity probe, WC-21, to …

Scientists have endeavored to understand sigma receptors for over 40 y. Although most
agree that they are important, there is little agreement on anything else. In their behavioral …

Abstract σ 2 Receptor subtype is overexpressed in a variety of human tumors, with σ 2
agonists showing antiproliferative effects towards tumor cells through multiple pathways that …

Despite the interest aroused by sigma receptors (SRs) in the area of oncology, their role in
tumor biology remains enigmatic. The predominant subcellular localization and main site of …

Sigma receptors have been implicated in a myriad of cellular functions, biological processes
and diseases. While the precise biological functions of sigma receptors have not been …

The chaperon protein sigma‐1 receptor (S1R) has been discovered over 40 years ago.
Recent pharmacological studies using S1R exogenous ligands demonstrated a promising …

SR31747A is a recently described sigma receptor ligand that binds SR31747A-binding
protein 1 (SR-BP) and emopamil-binding protein (EBP)(also called the sigma1 receptor and …

The sigma‐2 receptor is highly expressed in various rapidly proliferating cancer cells and
regarded as a cancer cell biomarker. Selective sigma‐2 ligands have been shown to …