[HTML][HTML] Validation of tag SNPs for multiple sclerosis HLA risk alleles across the 1000 genomes panel
Currently, the genetic variants strongly associated with risk for Multiple Sclerosis (MS) are
located in the Major Histocompatibility Complex. This includes DRB1* 15: 01 and DRB1* 15 …
located in the Major Histocompatibility Complex. This includes DRB1* 15: 01 and DRB1* 15 …
[HTML][HTML] Multiple Sclerosis Risk Variant HLA-DRB1*1501 Associates with High Expression of DRB1 Gene in Different Human Populations
A Alcina, MM Abad-Grau, M Fedetz, G Izquierdo… - PloS one, 2012 - journals.plos.org
The human leukocyte antigen (HLA) DRB1* 1501 has been consistently associated with
multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen …
multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen …
Opposing effects of the HLA-DRB1* 0301-DQB1* 0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel
G Benedek, T Paperna, N Avidan, I Lejbkowicz… - Genes & …, 2010 - nature.com
Different multiple sclerosis (MS) prevalence rates were reported for Muslim and Christian
Arabs in Israel. In this study, we evaluated whether associations of human leukocyte antigen …
Arabs in Israel. In this study, we evaluated whether associations of human leukocyte antigen …
HLA associations in South Asian multiple sclerosis
Background: Previous efforts to identify Human Leukocyte Antigen (HLA) gene associations
with multiple sclerosis (MS) in the South Asian population have been underpowered. Aim …
with multiple sclerosis (MS) in the South Asian population have been underpowered. Aim …
[PDF][PDF] Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
JR Oksenberg, LF Barcellos, BAC Cree… - The American Journal of …, 2004 - cell.com
An underlying complex genetic susceptibility exists in multiple sclerosis (MS), and an
association with the HLA-DRB1* 1501-DQB1* 0602 haplotype has been repeatedly …
association with the HLA-DRB1* 1501-DQB1* 0602 haplotype has been repeatedly …
A Taqman assay for high‐throughput genotyping of the multiple sclerosis‐associated HLA‐DRB1* 1501 allele
A Goris, A Walton, M Ban, B Dubois… - Tissue …, 2008 - Wiley Online Library
The human leukocyte antigen (HLA)‐DRB1* 1501 allele has long been established as the
main genetic risk factor for multiple sclerosis (MS), and it therefore follows that stratification …
main genetic risk factor for multiple sclerosis (MS), and it therefore follows that stratification …
[HTML][HTML] Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry
Multiple sclerosis (MS) is an autoimmune disease with high prevalence among populations
of northern European ancestry. Past studies have shown that exposure to ultraviolet …
of northern European ancestry. Past studies have shown that exposure to ultraviolet …
[HTML][HTML] High resolution haplotype analyses of classical HLA genes in families with multiple sclerosis highlights the role of HLA-DP alleles in disease susceptibility
K Osoegawa, LE Creary, G Montero-Martín… - Frontiers in …, 2021 - frontiersin.org
Multiple sclerosis (MS) susceptibility shows strong genetic associations with HLA alleles and
haplotypes. We genotyped 11 HLA genes in 477 non-Hispanic European MS patients and …
haplotypes. We genotyped 11 HLA genes in 477 non-Hispanic European MS patients and …
[HTML][HTML] An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 …
Background Multiple sclerosis (MS) is a complex trait in which genes in the MHC class II
region exert the single strongest effect on genetic susceptibility. The principal MHC class II …
region exert the single strongest effect on genetic susceptibility. The principal MHC class II …
[HTML][HTML] Highly conserved extended haplotypes of the major histocompatibility complex and their relationship to multiple sclerosis susceptibility
Objective To determine the relationship between highly-conserved extended-haplotypes
(CEHs) in the major histocompatibility complex (MHC) and MS-susceptibility. Background …
(CEHs) in the major histocompatibility complex (MHC) and MS-susceptibility. Background …