Biological assemblies provide inspiration for the development of new materials for a variety
of applications,. Our ability to realize this potential, however, is hampered by difficulties in …

Interest in the design of peptide-based fibrous materials is growing because it opens
possibilities to explore fundamental aspects of peptide self-assembly and to exploit the …

Our increasing understanding of peptide and protein folding and assembly raises new
possibilities for engineering novel self-assembling supramolecular structures and bio …

We have established a designed system comprising two peptides that coassemble to form
long, thickened protein fibers in water. This system can be rationally engineered to alter fiber …

Two stages in the rational redesign of a peptide‐based, self‐assembling fiber (SAF) are
described. The SAF system comprises two peptides designed to form an offset α‐helical …

Protein self‐assembly processes, by which polypeptides interact and independently form
multimeric structures, lead to a wide array of different endpoints. Structures formed range …

Scientists and bioengineers have dreamed of designing materials from the bottom up with
the finest detail and ultimate control at the single molecular level. The discovery of a class of …

Protein design studies using coiled coils have illustrated the potential of engineering simple
peptides to self-associate into polymers and networks. Although basic aspects of self …

In natural systems, directed self-assembly of structural proteins produces complex,
hierarchical materials that exhibit a unique combination of mechanical, chemical and …

Bioinspired fibrous materials that span the nano-to-meso scales have potentially broad
applications in nanobiotechnology; for instance, as scaffolds in 3D cell culture and tissue …