Alzheimer's disease (AD) is a familiar neurodegenerative disease in the elderly. In this
paper, we will review current viewpoints of microglial activation, inflammatory regulatory …

Alzheimer's disease is the world's most common dementing illness. It is pathologically
characterized by β-amyloid accumulation, extracellular senile plaques and intracellular …

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

Microglia are permanent immune cells of the central nervous system. Microglia play an
important role in the pathological process of Alzheimer's disease (AD). They are mainly …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain, which is
characterized by the formation of extracellular amyloid plaques (or senile plaques) and …

Contrary to early views, we now know that systemic inflammatory/immune responses
transmit to the brain. The microglia, the resident “macrophages” of the brain's innate immune …

Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

Pathophysiological processes of neurodegenerative diseases are not clearly defined.
However, an important body of evidence points toward the role of various inflammatory …

Inflammatory regulators, including endogenous anti-inflammatory systems, can down-
regulate inflammation thus providing negative feedback. Chronic inflammation can result …