Background Palliative treatment with the Fontan procedure has greatly improved survival for
children with functionally univentricular heart. Since Fontan performed the first successful …

Abstract Background The Fontan circulation is a palliative procedure performed in patients
with complex congenital heart disease (CHD), making transpulmonary blood flow …

Background—The Fontan procedure has improved survival in children with functionally
univentricular hearts. With time, however, complications such as reduced exercise capacity …

Aims An endothelin‐1 receptor blocker, shown to be effective in patients with pulmonary
arterial hypertension, might decrease pulmonary vascular resistance to increase cardiac …

Background: The Fontan procedure is currently the mainstay therapy for single functional
ventricles. However, with prolonged follow-up duration, various complications have been …

The Fontan operation is the final step of palliation for patients with a functionally single
ventricle. Since its introduction in the 1970s, the Fontan surgery has become part of a …

The Fontan operation is a common end point for children born with a single functional
ventricle. Fontan patients typically experience physiological deterioration leading to …

The Fontan operation is performed as a palliative procedure to improve survival in infants
born with a functionally univentricular circulation. The success of the operation is …

Background The clinical utility and long-term effects of endothelin receptor antagonists
(ERAs) in Fontan-palliated patients remain unclear and there are currently no approved …

Objective. Adult patients with a Fontan circulation tend to have diminished exercise capacity.
The principal objective of this study was to investigate the safety of the endothelin receptor …