Integrated transcriptomics and proteomics to reveal regulation mechanism and evolution of SmWRKY61 on tanshinone biosynthesis in Salvia miltiorrhiza and Salvia …

Y Chen, Y Wang, J Guo, J Yang, X Zhang… - Frontiers in plant …, 2022 - frontiersin.org
Tanshinones found in Salvia species are the main active compounds for the treatment of
cardiovascular and cerebrovascular diseases, but their contents are hugely different in …

Transcriptional Profiles of SmWRKY Family Genes and Their Putative Roles in the Biosynthesis of Tanshinone and Phenolic Acids in Salvia miltiorrhiza

H Yu, W Guo, D Yang, Z Hou, Z Liang - International Journal of Molecular …, 2018 - mdpi.com
Salvia miltiorrhiza Bunge is a Chinese traditional herb for treating cardiovascular and
cerebrovascular diseases, and tanshinones and phenolic acids are the dominated …

Tanshinone production could be increased by the expression of SmWRKY2 in Salvia miltiorrhiza hairy roots

C Deng, X Hao, M Shi, R Fu, Y Wang, Y Zhang, W Zhou… - Plant science, 2019 - Elsevier
Tanshinones are the main bioactive diterpenes in Salvia miltiorrhiza Bunge, are widely used
for treating cardiovascular and cerebrovascular diseases. However, the biosynthetic …

Transcription Factor SmWRKY1 Positively Promotes the Biosynthesis of Tanshinones in Salvia miltiorrhiza

W Cao, Y Wang, M Shi, X Hao, W Zhao… - Frontiers in Plant …, 2018 - frontiersin.org
Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of
cardiovascular diseases. WRKYs play important roles in plant metabolism, but their …

Molecular cloning and expression analysis of WRKY transcription factor genes in Salvia miltiorrhiza

C Li, D Li, F Shao, S Lu - BMC genomics, 2015 - Springer
Background WRKY proteins comprise a large family of transcription factors and play
important regulatory roles in plant development and defense response. The WRKY gene …

Molecular mechanism of elicitor-induced tanshinone accumulation in Salvia miltiorrhiza hairy root cultures

G Kai, P Liao, H Xu, J Wang, C Zhou, W Zhou… - Acta Physiologiae …, 2012 - Springer
To develop an optimal bioprocess for the production of tanshinone which is mainly used for
the treatment of cardiocerebral vascular disease, the tanshinone biosynthetic pathway …

Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla

Y Yin, H Fu, F Mi, Y Yang, Y Wang, Z Li, Y He, Z Yue - BMC Plant Biology, 2024 - Springer
Gentiana macrophylla is one of Chinese herbal medicines in which 4 kinds of iridoids or
secoiridoids, such as loganic acid, sweroside, swertiamarin, and gentiopicroside, are …

Overexpression of SmSCR1 Promotes Tanshinone Accumulation and Hairy Root Growth in Salvia miltiorrhiza

W Zhou, S Wang, Y Shen, Y Liu, I Maoz… - Frontiers in Plant …, 2022 - frontiersin.org
Lipid-soluble tanshinone is one of the main bioactive substances in the medicinal plant
Salvia miltiorrhiza, and its medicinal demand is growing rapidly. Yeast extract (YE) …

A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza

M Shi, R Zhu, Y Zhang, S Zhang, T Liu, K Li, S Liu… - Metabolic …, 2022 - Elsevier
Phenolic acids and tanshinones are main bioactive compounds produced in Salvia
miltiorrhiza widely used in treatment of cardiovascular diseases, which could be promoted …

Changes in secondary metabolites contents and stress responses in Salvia miltiorrhiza via ScWRKY35 overexpression: Insights from a wild relative Salvia castanea

G Zhang, Y Sun, N Ullah, D Kasote, L Zhu, H Liu… - Plant Physiology and …, 2024 - Elsevier
Salvia castanea Diels, a close wild relative to the medicinal plant, Salvia miltiorrhiza Bunge,
primarily grows in high-altitude regions. While the two species share similar active …