Objective: In this secondary analysis of data from the Veterans Affairs Augmentation and
Switching Treatments for Improving Depression Outcomes (VAST-D) study, the authors …

RATIONALE: Treatment guidelines for major depressive disorder (MDD) recommend a
continuous use of antidepressants for several weeks, while recent meta-analyses indicate …

Background: A subset of patients experience worsening of depressed mood after beginning
antidepressant treatment, which could represent the natural history of the illness or a …

The onset of action of antidepressant medications is commonly believed to require three or
more weeks based on clinical observation and corollary receptor-based hypotheses …

Background: This study aimed to replicate findings that length of episode prior to adequate
antidepressant treatment (theno-treatment interval') and premorbid neuroticism predict time …

Objective: Antidepressants (ADs) are the mainstay of treatment for major depressive
disorder (MDD). Despite their widespread usage, a consensus does not exist as to the …

Objective: While there is some indication from studies in the acute phase of antidepressant
treatment that there are differences in the timing of improvement in symptoms, relatively little …

Although antidepressant medications are effective in approximately 70% of patients with
major depressive disorder, they have a delayed onset of therapeutic effect. This latency is …

Early antidepressant response (2nd week) has been reported as the result of a true
antidepressant effect and a predictor of subsequent stable response. With the purpose to …

Background: We attempt to identify the time when patients whose conditions are unimproved
while receiving antidepressants are unlikely to respond and should have their treatment …