Studies have found that up to two-thirds of patients with major depressive disorder (MDD) do
not fully respond to the first antidepressant. While switching antidepressants is a common …

The timing of clinical drug effects in depression can be estimated by a variety of
methodological approaches, which might account for the heterogeneity of findings. We …

Background: Most natural history studies of affective disorders have emphasized the
prediction of eventual recovery. Little is known of changes over time in the immediate …

Even after optimal treatment with and response to antidepressant medications during acute
treatment of major depressive disorder, residual symptoms are common. Patients with …

Many sources purport that antidepressants have a delayed onset of action, measured in
weeks rather than days. Recent data using weekly or daily mood ratings demonstrate that …

In standard drug trials comparing antidepressants with placebo, a period of typically 3 weeks
is required before formal statistical significance between treatments is achieved. This delay …

Objective: This study sought to investigate the likelihood that subjects will respond to
continued antidepressant therapy when little or no benefit has yet been observed. Method …

There is a long-standing belief that elderly patients take longer to respond to antidepressant
treatment than younger patients, and thus, require longer trials to respond or remit. This has …

Objective Antidepressant switch is a commonly used strategy in the absence of an adequate
response, but optimum timing is not well established. We compared the efficacy of an early …

OBJECTIVE: The purpose of this study was to assess the time until onset of antidepressant
response with fluoxetine treatment. METHOD: The authors evaluated 182 outpatients with …