Extended exposure to trichostatin A after activation alters the expression of genes important for early development in nuclear transfer murine embryos

H Kang, S Roh - Journal of Veterinary Medical Science, 2011 - jstage.jst.go.jp
The low viability of embryos reconstructed by somatic cell nuclear transfer (SCNT) is
believed to be associated with epigenetic modification errors, and reduction of those errors …

48 EFFECTS OF TRICHOSTATIN A ON DEVELOPMENT OF BOVINE SOMATIC CELL NUCLEAR TRANSFER EMBRYOS

D Iwamoto, K Saeki, S Kishigami… - Reproduction …, 2007 - CSIRO Publishing
Although cloning by somatic cell nuclear transfer (SCNT) has been achieved in various
mammalian species, its efficiency has been very low (Han et al. 2003 Theriogenology 59, 33 …

Effects of trichostatin A on histone acetylation and methylation characteristics in early porcine embryos after somatic cell nuclear transfer

P Cong, K Zhu, Q Ji, H Zhao, Y Chen - Animal Science Journal, 2013 - Wiley Online Library
Until now, the efficiency of animal cloning by somatic cell nuclear transfer (SCNT) has
remained low. Efforts to improve cloning efficiency have demonstrated a positive role of …

45 EFFECT OF TRICHOSTATIN A TREATMENT ON THE TERM DEVELOPMENT OF SOMATIC CELL NUCLEAR TRANSFER RABBIT EMBRYOS

Q Meng, Z Polgar, J Liu, A Dinnyes - Reproduction, Fertility and …, 2007 - CSIRO Publishing
The efficiency of somatic cell nuclear transfer (SCNT) is low in the rabbit. So far, there have
been few live births reported and most clones died within the first 3 weeks after birth. It has …

Comparison of Blastocyst Development between Cat-Cow and Cat-Pig Interspecies Somatic Cell Nuclear Transfer Embryos Treated with Trichostatin A

LTK Do, M Wittayarat, Y Sato, K Chatdarong… - Biology Bulletin, 2021 - Springer
We previously demonstrated that the histone deacetylase inhibitor, trichostatin A (TSA),
improves the development of cat-cow interspecies somatic cell nuclear transfer (iSCNT) …

Trichostatin A and nuclear reprogramming of cloned rabbit embryos

LH Shi, JS Ai, YC Ouyang, JC Huang… - Journal of animal …, 2008 - academic.oup.com
To investigate the influence of histone deacetylases on nuclear reprogramming after nuclear
transfer, we treated the cloned embryos with a histone deacetylase inhibitor, Trichostatin A …

Trichostatin A promotes the development of bovine somatic cell nuclear transfer embryos

MJ Lee, SW Kim, HG Lee, GS Im, BC Yang… - … of Reproduction and …, 2011 - jstage.jst.go.jp
We studied the effects of trichostatin A (TSA), a histone deacetylase inhibitor, on the
development of bovine somatic cell nuclear transfer (SCNT) embryos by investigating (1) the …

[HTML][HTML] Effects of trichostatin A on in vitro development of porcine embryos derived from somatic cell nuclear transfer

YI Jeong, CH Park, HS Kim, YW Jeong… - … journal of animal …, 2013 - ncbi.nlm.nih.gov
Many different approaches have been developed to improve the efficiency of animal cloning
by somatic cell nuclear transfer (SCNT), one of which is to modify histone acetylation levels …

96 TRICHOSTATIN A IMPROVED THE QUALITY OF RABBIT NUCLEAR TRANSFER EMBRYOS

J Xu, LY Sung, J Zhang, X Tian, YE Chen… - Reproduction …, 2006 - CSIRO Publishing
Nuclear reprogramming is dependent upon a number of factors, including chromatin
organization and modification. Trychostatin A (TSA), a histone deacetylase inhibitor, was …

Trichostatin A alters the expression of cell cycle controlling genes and microRNAs in donor cells and subsequently improves the yield and quality of cloned bovine …

M Saini, NL Selokar, T Revey, SK Singla, MS Chauhan… - Theriogenology, 2014 - Elsevier
Trichostatin A (TSA), a histone deacetylase inhibitor, has been used to improve nuclear
reprogramming in somatic cell nuclear transfer embryos. However, the molecular …