Innate immune regulations and liver ischemia-reperfusion injury

L Lu, H Zhou, M Ni, X Wang, R Busuttil… - …, 2016 - journals.lww.com
Liver ischemia reperfusion activates innate immune system to drive the full development of
inflammatory hepatocellular injury. Damage-associated molecular patterns (DAMPs) …

[HTML][HTML] Liver ischemia and reperfusion injury: new insights into mechanisms of innate—adaptive immune-mediated tissue inflammation

Y Zhai, RW Busuttil, JW Kupiec-Weglinski - American Journal of …, 2011 - Elsevier
Ischemia and reperfusion injury (IRI) is a dynamic process that involves two distinctive yet
interrelated phases of ischemic organ damage and inflammation-mediated reperfusion …

Role of immuno-inflammatory signals in liver ischemia-reperfusion injury

C Kaltenmeier, R Wang, B Popp, D Geller, S Tohme… - Cells, 2022 - mdpi.com
Ischemia reperfusion injury (IRI) is a major obstacle in liver resection and liver
transplantation. The initial step of IRI is mediated through ischemia which promotes the …

Ischaemia–reperfusion injury in liver transplantation—from bench to bedside

Y Zhai, H Petrowsky, JC Hong, RW Busuttil… - Nature reviews …, 2013 - nature.com
Ischaemia–reperfusion injury (IRI) in the liver, a major complication of haemorrhagic shock,
resection and transplantation, is a dynamic process that involves the two interrelated phases …

[HTML][HTML] Mechanistic insight and clinical implications of ischemia/reperfusion injury post liver transplantation

J Liu, K Man - Cellular and molecular gastroenterology and …, 2023 - Elsevier
Ischemia/reperfusion injury is an inevitable process during liver transplantation and can lead
to a high incidence of early allograft dysfunction and graft failure. The mechanism of hepatic …

Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity

H Hirao, K Nakamura… - … reviews Gastroenterology & …, 2022 - nature.com
Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

[HTML][HTML] Targeting the hepatic microenvironment to improve ischemia/reperfusion injury: new insights into the immune and metabolic compartments

F Gao, X Qiu, K Wang, C Shao, W Jin, Z Zhang… - Aging and …, 2022 - ncbi.nlm.nih.gov
Hepatic ischemia/reperfusion injury (IRI) is mainly characterized by high activation of
immune inflammatory responses and metabolic responses. Understanding the molecular …

Dual effect of hepatic macrophages on liver ischemia and reperfusion injury during liver transplantation

TF Lu, TH Yang, CP Zhong, C Shen, WW Lin… - Immune …, 2018 - synapse.koreamed.org
Ischemia-reperfusion injury (IRI) is a major complication in liver transplantation (LT) and it is
closely related to the recovery of grafts' function. Researches has verified that both innate …

CXCR3+ CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury

Y Zhai, X Shen, WW Hancock, F Gao… - The Journal of …, 2006 - journals.aai.org
Abstract Ischemia-reperfusion injury (IRI), an innate immune-dominated inflammatory
response, develops in the absence of exogenous Ags. The recently highlighted role of T …

Sterile inflammation in hepatic ischemia/reperfusion injury: present concepts and potential therapeutics

RF van Golen, MJ Reiniers, PB Olthof… - Journal of …, 2013 - Wiley Online Library
Ischemia and reperfusion (I/R) injury is an often unavoidable consequence of major liver
surgery and is characterized by a sterile inflammatory response that jeopardizes the viability …