Recent studies have indicated that minocycline, a microglia inhibitor, could potentially be
used as an antinociceptive agent in pain management, although the underlying …

The present study investigates the analgesic effect of minocycline, a semi-synthetic
tetracycline antibiotic, in a rat model of inflammation-induced visceral pain. Inflammation …

Neuropathic pain is an intractable clinical problem, affecting millions of people worldwide.
Preemptive administration of minocycline has been confirmed useful for treating neuropathic …

Background It has been reported that neuropathic pain can be overcome by targeting the
NR2B subunit of N-methyl-D-aspartate receptors (NR2B). This study aimed to investigate the …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

Activation of glutamate receptors and glial cells in the spinal dorsal horn are two
fundamental processes involved in the pathogenesis of various pain conditions, including …

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

Background and Objectives Minocycline is a second-generation tetracycline with multiple
biological effects, including inhibition of microglial activation. Recently, microglial activation …

Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …

Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …