Secukinumab shows high efficacy irrespective of HLA‐Cw6 status in patients with moderate‐to‐severe plaque‐type psoriasis: results from extension phase of the …

M Papini, F Cusano, M Romanelli… - British Journal of …, 2019 - academic.oup.com
DEAR EDITOR, Recent studies have shown that biological drugs approved for treating
psoriasis and psoriatic arthritis are not effective in all patients, and that variations in the …

Secukinumab dosing every 2 weeks demonstrated superior efficacy compared with dosing every 4 weeks in patients with psoriasis weighing 90 kg or more: results of …

M Augustin, K Reich, P Yamauchi… - British Journal of …, 2022 - academic.oup.com
Background Obesity is a common comorbidity of psoriasis and can attenuate response to
biologic treatment. Objectives To investigate the efficacy, safety and tolerability of …

Secukinumab in pediatric patients with plaque psoriasis: pooled safety analysis from two phase 3 randomized clinical trials

M Sticherling, AF Nikkels, AM Hamza, P Kwong… - American journal of …, 2023 - Springer
Background Plaque psoriasis affects~ 1% of the pediatric population, negatively impacting
quality of life. The efficacy and safety of secukinumab in pediatric patients with moderate to …

[HTML][HTML] Efficacy and safety of secukinumab in the treatment of moderate to severe plaque psoriasis: a meta-analysis of randomized controlled trials

HZ Xiong, JY Gu, ZG He, WJ Chen… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Psoriasis is a chronic inflammatory skin disease with high rate of recurrence. New anti-
interleukin-17 (IL-17) and anti-IL17RA biologics are in Phase 3 clinical trials and may prove …

A propensity score-matched study on the changes of TB status and TB-IGRA values in patients with psoriasis with latent TB receiving secukinumab

Y Xiao, W Mi, J Wang, D Wen, Y Wang, Y Gu… - Dermatology and …, 2023 - Springer
Introduction The utilization of biologics in patients with psoriasis with latent tuberculosis
infection (LTBI) has garnered significant attention. Although the tuberculosis (TB) safety …

Efficacy of secukinumab in the treatment of moderate to severe plaque psoriasis in the North American subgroup of patients: pooled analysis of four phase 3 studies

D Pariser, E Frankel, J Schlessinger, Y Poulin… - Dermatology and …, 2018 - Springer
Introduction Demographic and disease characteristics may impact response to psoriasis
therapies. The objective of this study is to explore the safety and efficacy profile of …

[HTML][HTML] Persistence of secukinumab in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis

E Conesa-Nicolás, MH García-Lagunar… - Farmacia …, 2021 - Elsevier
Objective To determine persistence of treatment with secukinumab across its different
indications. Method This is a retrospective descriptive observational study including adult …

Secukinumab provides sustained low rates of radiographic progression in psoriatic arthritis: 52-week results from a phase 3 study, FUTURE 5

D Van Der Heijde, PJ Mease, RBM Landewé… - …, 2020 - academic.oup.com
Objective To evaluate the effect of secukinumab on radiographic progression through 52
weeks in patients with PsA from the FUTURE 5 study. Methods Patients with active PsA …

Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis

L Cai, JZ Zhang, X Yao, J Gu, QZ Liu… - Chinese Medical …, 2020 - mednexus.org
Background: Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the
Chinese population. Many patients are not well controlled by conventional treatments, thus …

Secukinumab (AIN457) for the treatment of psoriasis

A Lopez-Ferrer, E Vilarrasa, L Puig - Expert Review of Clinical …, 2015 - Taylor & Francis
Psoriasis is a chronic inflammatory disease with a multifactorial origin that appears in
patients with genetic predisposition and is induced by environmental factors, and …