This paper describes the roles of the astrocytic Na+, K+-ATPase for K+ homeostasis in brain.
After neuronal excitation it alone mediates initial cellular re-accumulation of moderately …

Neuronal excitation increases extracellular K+ concentration ([K+] o) in vivo and in
incubated brain tissue by stimulation of postsynaptic glutamatergic receptors and by channel …

The importance of astrocytic K+ uptake for extracellular K+([K+] e) clearance during
neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It …

During neuronal activity in the brain, extracellular K+ rises and is subsequently removed to
prevent a widespread depolarization. One of the key players in regulating extracellular K+ is …

Key points Management of glutamate and K+ in brain extracellular space is of critical
importance to neuronal function. The astrocytic α2β2 Na+/K+‐ATPase isoform combination …

Brain excitation increases neuronal Na+ concentration by 2 major mechanisms:(i) Na+ influx
caused by glutamatergic synaptic activity; and (ii) action-potential-mediated depolarization …

Network activity in the brain is associated with a transient increase in extracellular K+
concentration. The excess K+ is removed from the extracellular space by mechanisms …

Initial clearance of extracellular K+([K+] o) following neuronal excitation occurs by astrocytic
uptake, because elevated [K+] o activates astrocytic but not neuronal Na+, K+-ATPases …

Neuronal signaling in the central nervous system (CNS) associates with release of K+ into
the extracellular space resulting in transient increases in [K+] o. This elevated K+ is swiftly …

Abstract The Na, K-ATPase has been only partially purified from nervous tissue, yet it is clear
that two forms (and α+) of the catalytic subunit are present. α is a component subunit of the …